Summary
The vascular system in the inferior mesenteric ganglion of the guinea pig was studied to clarify the transport pathway of transmitters released by the small intensely fluorescent (SIF) cells to the principal ganglionic neurons. Reconstruction of about 1500 1-μm-thick serial sections of the ganglion demonstrated its portal system. SIF cells were tightly packed and formed two or three clusters under the capsule of the ganglion. Branches from the inferior mesenteric artery ran directly toward these clusters and broke up into a number of coiled and looped sinusoid capillaries among the SIF cells. They then drained into a large sinus surrounding the clusters in the ganglion. Capillaries were derived from this sinus and ramified among the principal ganglionic neurons. After supplying the neurons, these vessels drained into veins surrounding the ganglion. Therefore, as we observed two distinct groups of capillaries, we call this sinus the “intraganglionic portal sinus”. All the transmitters secreted from the SIF cells are collected into this intraganglionic portal sinus and are then conveyed through the capillaries to the principal ganglionic neurons.
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References
Abe H, Watanabe H, Yamamoto T (1983) Relationship between granule-containing cells and blood vessels in the rat autonomic ganglia. Anat Rec 205:65–72
Chiba T, Masuko S (1989) Coexistence of multiple peptides in small intensely fluorescent (SIF) cells of inferior mesenteric ganglion of the guinea pig. Cell Tissue Res 255:523–527
Chiba T, Williams TH (1975) Histofluorescence characteristics and quantification of small intensely fluorescent (SIF) cells in sympathetic ganglia of several species. Cell Tissue Res 162:331–341
Chiba T, Murata Y, Koike T (1981) Plasticity of pheochromocytoma (PC12) cells demonstrated by nerve growth factor or glucocorticoid treatment: a catecholamine fluorescence and electron microscopic investigation. Biomed Res 2:618–628
Doupe AJ, Patterson PH, Landis SC (1985) Small intensely fluorescent cells in culture: role of glucocorticoids and growth factors in the development and interconversions with other neural crest derivatives. J Neurosci 5:2143–2160
Elfvin L-G, Hökfelt T, Goldstein M (1975) Fluorescence microscopical, immunohistochemical and ultrastructural studies on sympathetic ganglia of the guinea pig with special reference to the SIF cells and their catecholamine content. J Ultrastruct Res 51:377–396
Heym C, Williams TH (1979) Evidence for autonomic paraneurons in sympathetic ganglia of a shrew (Tupaia glis). J Anat 129:151–164
Morris JL, Gibbins IL (1987) Neuronal colocalization of peptides, catecholamines, and catecholamine synthesizing enzymes in guinea pig paracervical ganglia. J Neurosci 7:3117–3130
Schultzberg M, Hökfelt T, Lundberg JM, Dalsgaard CJ, Elfvin L-G (1983) Transmitter histochemistry of autonomic ganglia. In: Elfvin L-G (ed) Autonomic ganglia. Wiley, New York, pp 205–233
Williams TH, Black AC Jr, Chiba T, Jew J (1976a) Interneuron/SIF cells in sympathetic ganglia of various mammals. In: Coupland RE, Fujita T (eds) Chromaffin, enterochromaffin and related cells. Elsevier, Amsterdam, pp 95–116
Williams TH, Chiba T, Black AC Jr, Bhalla RC, Jew J (1976b) Species differences in structure and function of SIF cells in the superior cervical ganglion. In: Eränkö O (eds) SIF cells. Government Printing Office, Washington DC, pp 143–162
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Tanaka, K., Chiba, T. Intraganglionic portal sinus located between small intensely fluorescent (SIF) cells and principal ganglionic neurons in the inferior mesenteric ganglion of the guinea pig. Cell Tissue Res 265, 57–61 (1991). https://doi.org/10.1007/BF00318139
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DOI: https://doi.org/10.1007/BF00318139