Summary
Alterations in the pattern of pulmonary metastasis of patients with osteosarcoma treated with adjuvant chemotherapy were studied. Thirty two patients who were treated with both radical surgery and adjuvant chemotherapy were observed (chemotherapy group). As a control, sixty two patients treated with radical surgery alone were also assessed (non-chemotherapy group). The chemotherapy group demonstrated a reduction in the number and a delay in the appearance of metastases. The tumour doubling time did not differ between the chemotherapy and non-chemotherapy groups. The initial site of metastasis among the chemotherapy group was most commonly in the lower lung field, whereas among the non-chemotherapy group it was usually to the middle lung field. The chemotherapy group survived longer than the non-chemotherapy group after developing pulmonary metastases. Histological examination showed that the metastatic foci simulated the primary sites.
Résumé
On a étudié les modifications de l'aspect des métastases pulmonaires chez des malades porteurs d'un ostéosarcome et traités par chimiothérapie complémentaire. Trente-deux malades traités à la fois par chirurgie radicale et chimiothérapie ont été examinés (groupe avec chimiothérapie). Soixante-deux malades traités seulement par chirurgie radicale (groupe sans chimiothérapie) ont également été suivis, constituant un groupe de contrôle. Le groupe avec chimiothérapie a présenté une diminution du nombre ainsi qu'un retard à l'apparition des métastases. Le temps de doublement de ces tumeurs ne diffère pas entre les deux groupes. La localisation initiale des métastases dans le groupe avec chimiothérapie est le plus souvent la base du poumon, tandis que dans le groupe sans chimiothérapie c'est habituellement la partie moyenne du poumon. Après apparition des métastases pulmonaires la durée de survie est plus importante dans le groupe avec chimiothérapie que dans l'autre. L'examen histologique montre que les foyers métastatiques sont identiques à la localisation initiale de la tumeur.
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Yamaguchi, H., Nojima, T., Yagi, T. et al. The alteration in the pattern of pulmonary metastasis with adjuvant chemotherapy in osteosarcoma. International Orthopaedics 12, 305–308 (1988). https://doi.org/10.1007/BF00317829
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DOI: https://doi.org/10.1007/BF00317829