Summary
Cerebral ischemia of 15 min was produced in rats by increasing intracranial pressure above the systolic blood pressure level by infusing artificial cerebrospinal fluid into the cisterna magna. Pulmonary edema was prevented by blocking the vasomotor response with a ganglioplegic agent, and reducing the fluid load by peritoneal dialysis. The EEG flattened after 10.1±1.5 sec, followed by a dilatation of a pupils after 1–2 min. The EEG began to recover in 21 of 32 rats after 8 to 35 min of recirculation. Spectral analysis revealed an initial return of slow waves and spindles followed by continuous fast frequency activity. The EEG did not recover or was secondarily suppressed in 12 animals after a few hours. Electrophysiological recovery depended on the cardiocirculatory and respiratory state, the recovery being optimal in animals with mild hypertension and a normal acidbase status of the blood.
Zusammenfassung
Die Durchblutung des Rattenhirnes wurde für eine Dauer von 15 min durch intrakranielle Drucksteigerung vollständig unterbrochen (Kompressionsischämie). Zu diesem Zweck wurde der intrakranielle Druck durch Infusion von künstlichem Liquor in die Cisterna magna über den Blutdruck angehoben. Um ein Lungenödem zu verhindern, wurde die vasomotorische Antwort mit einem Ganglio-plegicum blockiert und die Flüssigkeitszufuhr durch Peritonealdialyse ausgeglichen. Das EEG wurde 10.1±1.5 sec nach Beginn der Ischämie isoelektrisch, eine Erweiterung der Pupillen trat nach 1–2 min ein. In 21 von 32 Tieren begann sich das EEG im Anschluß an die Ischämie innerhalb von 8–35 min zu erholen. Die Spektralanalyse des EEGs ergab, daß die langsamen Frequenzen schneller als die raschen Frequenzen wiederkehrten. Bei 12 Tieren erholte sich das EEG nicht oder wurde nach einigen Stunden sekundär isoelektrisch. Die elektrophysiologische Erholung war abhängig vom Verhalten des Kreislaufs und der Atmung. Optimale Ergebnisse wurden bei leichter postischämischer Hypertension und einem ausgeglichenen Säure-Basen-Gleichgewicht des Blutes erzielt.
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This investigation was supported by a research grant from the Deutsche Forschungsgemeinschaft
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Kawakami, S., Hossmann, K.A. Electrophysiological recovery after compression ischemia of the rat brain. J. Neurol. 217, 31–42 (1977). https://doi.org/10.1007/BF00316314
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DOI: https://doi.org/10.1007/BF00316314