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Ivermectin binds avidly to plasma proteins

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Human pharmacokinetic data on the new antiparasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2±4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.

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Klotz, U., Ogbuokiri, J.E. & Okonkwo, P.O. Ivermectin binds avidly to plasma proteins. Eur J Clin Pharmacol 39, 607–608 (1990).

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