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Ultrastructural pathology of the peripheral nervous system

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Summary

The present paper gives an introduction to fundamental pathologic features of various diseases of the peripheral nervous system, such as Wallerian degeneration, axonal degeneration, segmental degeneration, primary impairment of the endoneural interstitium. It is based on electron-microscope analysis. The range of reactions available to the peripheral nervous system is limited; thus noxious influences of various etiologies will act via largely common pathogenic mechanisms to produce similar morphologic changes.

Zusammenfassung

Es wird eine Einführung in die grundlegenden pathologischen Befunde bei Erkrankungen des peripheren Nervensystems gebracht. Diese betreffen die Wallersche sekundäre Degeneration, die primär axonale Degeneration, die segmentale Entmarkung und die sogenannte interstitielle Neuritis. Die Darstellung beruht auf neuen Erkenntnissen der elektronenmikroskopischen Forschung. Es wird gezeigt, daß formal-pathogenetisch die Reaktionsbreite des peripher-nervösen Gewebes beschränkt ist, wobei ätiologisch verschiedene Noxen über wahrscheinlich weitgehend gemeinsame pathogenetische Grundfaktoren ziemlich gleichartige morphologische Veränderungen hervorrufen.

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  1. Department of Neurology, Berne University, Berne

    A. Bischoff

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Supported by the Swiss National Fund (3. 747. 72).

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Bischoff, A. Ultrastructural pathology of the peripheral nervous system. Z. Neurol. 205, 257–274 (1973). https://doi.org/10.1007/BF00316020

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