Summary
Intercellular junctions within the villous stroma and the cytotrophoblastic layer of the human full term placenta were investigated using thin sectioning and freeze-fracturing. Numerous maculae adherentes (desmosomes) were found between the cytotrophoblast cells and the syncytiotrophoblast. This junction type was also seen connecting adjacent cytotrophoblast cells. Large gap junctions were frequently observed in contact areas of perikarya or at processes of adjacent fibroblasts. They often exhibited a peculiar pattern of their particles on the P-face of the membrane. Small rows of junctional particles were found on the P-faces of interconnected smooth muscle cells and gap junctions frequently bridged myoendothelial and interendothelial contact zones.
The significance of the junctional complexes is discussed in relation to functional systems within the villous stroma of the human full term placenta.
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References
Becker, K., Seifert, K.: Die Ultrastruktur der Kapillarwand in der menschlichen Placenta zur Zeit der schwangerschaftsmitte. Z. Zellforsch. 65, 380–396 (1963)
Boyd, J.D., Hamilton, W.J.: Electron microscopic observations on the cytotrophoblast contribution to the syncyticum in the human placenta. J. Anat. 100, 535–548 (1966)
Cavicchia, J.C.: Junctional complexes in the trophoblast of the human full term placenta. J. Anat. 108, 339–346 (1971)
Dempsey, E.W.: The development of capillaries in the villi of early human placenta. Amer. J. Anat. 134, 221–238 (1972)
Enders, A.C.: A comparative study of the fine strucutre of the trophoblast in several hemochorial placentas. Am. J. Anat. 116, 29–68 (1965)
Fawcett, D.W.: Cell interaction in the reproductive system. In: Electron Microscopy, Vol. III, pp. 643–650, J.H. Sturgess (ed.). Toronto: Imperial Press Ltd. 1978
Forssmann, W.G., Ito, S., Weihe, E., Aoki, A., Dym, M., Fawcett, D.W.: An improved perfusion fixation method for the testis. Anat. Rec. 188, 307–314 (1977)
Gilula, N., Reeves, O., Steinbach, A.: Metabolic coupling, ionic coupling, and cell contacts. Nature (London) 235, 262–265 (1972)
Heinrich, D., Metz, J., Raviola, E., Forssmann, W.G.: Ultrastructure of perfusion-fixed fetal capillaries in the human placenta. Cell. Tissue Res. 172, 157–169 (1976)
Hertig, A.T.: Angiogenesis in the early human chorion and in the primary placenta of the macaque monkey. Contrib. Embryol. Carneg. Instn. 25, 37–81 (1935)
Karnovsky, M.J.: Use of ferrocyanide-reduced osmium tetroxide in electron microscopy. J. cell Biol. 50, ASCB abstracts, 146 (1971)
Kaufmann, P., Stark, J., Stegner, H.E.: The villous stroma of the human placenta: I. The ultrastructure of fixed connective tissue cells. Cell Tissue Res. 177, 105–121 (1977)
Luft, J.H.: Improvements in epoxy-resin embedding methods. J. Biophys. Biochem. Cytol. 9, 409–414 (1961)
Metz, J., Weihe, E.: Intercellular junctions within the human full term placenta: I. Syncytiotrophoblastic layer. Anat. Embryol. 158, 41–50 (1979)
Nikolov, S., Schiebler, T.H.: Über das fetale Gefäßsystem der reifen menschlichen Placenta. Z. Zellforsch. 139, 333–350 (1973)
Tighe, J.R., Garrod, P.R., Currau, R.C.: The trophoblast of the human chorionic villus. J. Path. Bact. 93, 559–567 (1967)
Vacek, Z.: Derivation and ultrastructure of the stroma cells of the human chorionic villus. Folia. morph. (Praha) 18, 1–13 (1970)
Weihe, E., Hartschuh, W., Metz, J., Brühl, U.: The use of ionic lanthanum as a diffusion tracer and as a marker of calcium binding sites. Cell Tissue Res. 178, 285–302 (1977)
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Metz, J., Weihe, E. Intercellular junctions in the full term human placenta. Anat Embryol 158, 167–178 (1980). https://doi.org/10.1007/BF00315904
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DOI: https://doi.org/10.1007/BF00315904