Skip to main content

Effect of diuretics on captopril-induced urinary zinc excretion


The urinary zinc/creatinine ratio has been measured in five groups of patients with essential hypertension and in a group of healthy controls. The first four groups of patients consisted of subjects being treated for at least three months with captopril alone, hydrochlorothiazide alone, captopril plus hydrochlorothiazide, or captopril and furosemide. The fifth group comprised hypertensive patients not on any medication.

The first four patient groups exhibited significantly increased urinary zinc/creatinine ratios when compared to the control and untreated hypertensive groups, but in the two combination regimens there was little zincuria.

It is suggested that both diuretics inactivate the zincuric effect of captopril by binding to its sulphhydryl group within the tubular lumen.

This is a preview of subscription content, access via your institution.


  1. Golik A, Modai D, Weissgarten J, Cohen W, Averbukh Z, Sigler E, Zaidenstein R, Shaked U (1987) Hydro-chlorothiazideamiloride causes excessive urinary zinc excretion. Clin Pharmacol Ther 42: 42–44

    Google Scholar 

  2. Wester PO (1980) Urinary zinc excretion during treatment with different diuretics. Acta Med Scand 208: 2609–212

    Google Scholar 

  3. Abu-Hamdan DK, Desai H, Sonheimer J, Flicetta J, Mahajan S, McDonald F (1988) Taste acuity and zinc metabolism in captopril treated hypertensive male patients. Am J Hypertens 1: 303S-308S

    Google Scholar 

  4. Weinberger MH (1983) Influence of an angiotensin converting enzyme inhibitor on diuretic induced metabolic effects in hypertension. Hypertension 5: 132S-138S

    Google Scholar 

  5. Weinberger MH (1982) Comparison of captopril and hydrochlorothiazide alone and in combination in mild to moderate hypertension. Br J Clin Pharmacol 2: 127S-131S

    Google Scholar 

  6. Prasad AS (1983) Clinical, biochemical and nutritional spectrum of zinc deficiency in human subjects. An Update. Nutr Rev 41: 197–208

    Google Scholar 

  7. Prasad AS (1985) Clinical, endocrinological and biochemical effects of zinc deficiency. Clin Endocrinol Metab 14: 567–589

    Google Scholar 

  8. Zumkley H, Bertram HP, Vetter H, Zidek W, Losse H (1985) Zinc metabolism during captopril treatment. Horm Metabol Res 17: 256–258

    Google Scholar 

  9. Smith AJ, Hoorntje SJ, Donker AJM (1983) Zinc deficiency during captopril treatment. Nephron 34: 196–198

    Google Scholar 

  10. Pak CYC, Ruskin B, Diller E (1972) Enhancement of renal excretion of zinc by hydrochlorothiazide. Clin Chim Acta 39: 511–517

    Google Scholar 

  11. Wester PO (1980) Urinary zinc excretion during treatment with different diuretics. Acta Med Scand 208: 209–212

    Google Scholar 

  12. Abu-Hamdan DK, Migdal SD, Whitehouse R, Rabbani P, Prasad AS, McDonald FD (1981) Renal handling of zinc: effect of cysteine infusion. Am J Physiol 241: F487-F494

    Google Scholar 

  13. Reyes AJ, Leary WP (1981) A mathematical model for the clinical pharmacology of diuretics. Curr Ther Res 30: 227–235

    Google Scholar 

  14. Ellison DH, Velazauez H, Wright FS (1987) Thiazide-sensitive sodium chloride cotransport in early distal tubule. Am J Physiol 253: F547-F554

    Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Golik, A., Averbukh, Z., Cohn, M. et al. Effect of diuretics on captopril-induced urinary zinc excretion. Eur J Clin Pharmacol 38, 359–361 (1990).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

Key words

  • urinary zinc
  • captopril
  • furosemide
  • hydrochlorothiazide
  • hypertension