Skip to main content
Log in

The acute effects of amiloride and potassium canrenoate on digoxin-induced positive inotropism in healthy volunteers

  • Letter To The Editors
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Waldorff S, Berning J, Buch H, Steiness E (1982) Systolic time intervals during spironolactone treatment of digitalized and non-digitalized patients with ischaemic heart disease. Eur J Clin Pharmacol 21: 269–273

    Google Scholar 

  2. Waldorff S, Hansen PB, Kjaergard H, Buch J, Egeblad H, Steiness E (1981) Amiloride-induced changes in digoxin dynamics and kinetics: abolition of digoxin-induced inotropism with amiloride. Clin Pharmacol Ther 30: 172–176

    Google Scholar 

  3. Waldorff S, Hansen P, Egelblad H, Berning J, Buch H, Kjaergard H, Steiness E (1983) Interactions between digoxin and potassium-sparing diuretics. Clin Pharmacol Ther 33: 418–423

    Google Scholar 

  4. Kennedy RH, Akera T, Brody TM (1985) Suppression of positive inotropic and toxic effects of cardiac glycosides by amiloride. Eur J Pharmacol 115: 199–210

    Google Scholar 

  5. Cheitlin DM, Byrd R, Benowitz N, Liu E, Modin G (1991) Amiloride improves haemodynamics in patients with chronic congestive heart failure treated with chronic digoxin and diuretics. Cardiovasc Drugs Ther 5: 719–726

    Google Scholar 

  6. Waldorff S, Buch H (1979) Canrenoate — a spironolactone metabolite. Acute cardiac effects in digitalized patients. Eur J Cardiol 10: 143–149

    Google Scholar 

  7. Nicholls MG, Espiner EA, Hughes H, Rogers T (1976) Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure. Br Heart J 38: 1025–1030

    Google Scholar 

  8. Millar JA, Fraser R, Mason P, Leckie B, Cumming AMM, Robertson JIS (1984) Metabolic effects of high dose amiloride and spironolactone: a comparative study in normal subjects. Br J Clin Pharmacol 18: 369–375

    Google Scholar 

  9. Lefer AM, Sayers G (1964) Antagonism of the inotropic action of ouabain by aldosterone. Am J Physiol 208: 649–654

    Google Scholar 

  10. Appel WC, Vincenzi FF (1973) Positive inotropic effect of cardiotonic steroids: differential antagonism by aldosterone. J Pharmacol Exp Ther 187: 112–120

    Google Scholar 

  11. Debetto P, Luciani S, Tessari M, Floreani M, Carpenedo F (1989) Inhibition of Na+ Ca2+ exchange by amiloride acting from opposite sides of cardiac sarcolemma. Biochem Pharmacol 38: 1137–1145

    Google Scholar 

  12. Floreani M, Luciani SS (1984) Amiloride: relationship between cardiac effects and inhibition of Na+/Ca+ exchange. Eur J Pharmacol 105: 317–322

    Google Scholar 

  13. Waldorff S, Andersen JD, Heeboll-Nielsen N, Nielsen OG, Moltke E, Sorensen U, Steiness E (1987) Spironolactone-induced changes in digoxin kinetics. Clin Pharmacol Ther 24: 162–167

    Google Scholar 

  14. Stern HC, Matthews JH, Belz GG (1984) Influence of dihydralazine induced afterload reduction on systolic time intervals and echocardiography in healthy subjects. Br Heart J 52: 435–439

    Google Scholar 

  15. Hollander M, Wolf AD (1973) Nonparametric statistical methods. Wiley, New York, pp 138–153

    Google Scholar 

  16. Steyn AGW, Smit CF, Du Toit SHC (1989) Moderne Statistiek vir die Praktyk. Van Schaik, Pretoria, pp 504–508

    Google Scholar 

  17. Lewis RP, Rittgers SE, Forester WF, Boudoulas H (1977) A critical review of systolic time intervals. Circulation 56: 146–158

    Google Scholar 

  18. Yeh BK, Chiang BN, Sung P-K (1976) Antiarrhythmic activity of potassium canrenoate in man. Am Heart J 92: 308–314

    Google Scholar 

  19. Weis M, Sziegoleit W, Fahr A, Förster W (1983) Rapid achievement of a serum concentration plateau of digoxin through controlled infusion. Eur J Clin Pharmacol 25: 455–457

    Google Scholar 

  20. Buch J, Egeblad H, Hansen PB, Kjaergard H, Waldorff S, Steiness E (1980) Correlation between changes in systolic time intervals and left ventricular end-diastolic diameter after preload reduction. Br Heart J 44: 668–671

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Richter, J.P., De Sommers, K., Snyman, J.R. et al. The acute effects of amiloride and potassium canrenoate on digoxin-induced positive inotropism in healthy volunteers. Eur J Clin Pharmacol 45, 195–196 (1993). https://doi.org/10.1007/BF00315506

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00315506

Key words

Navigation