References
Waldorff S, Berning J, Buch H, Steiness E (1982) Systolic time intervals during spironolactone treatment of digitalized and non-digitalized patients with ischaemic heart disease. Eur J Clin Pharmacol 21: 269–273
Waldorff S, Hansen PB, Kjaergard H, Buch J, Egeblad H, Steiness E (1981) Amiloride-induced changes in digoxin dynamics and kinetics: abolition of digoxin-induced inotropism with amiloride. Clin Pharmacol Ther 30: 172–176
Waldorff S, Hansen P, Egelblad H, Berning J, Buch H, Kjaergard H, Steiness E (1983) Interactions between digoxin and potassium-sparing diuretics. Clin Pharmacol Ther 33: 418–423
Kennedy RH, Akera T, Brody TM (1985) Suppression of positive inotropic and toxic effects of cardiac glycosides by amiloride. Eur J Pharmacol 115: 199–210
Cheitlin DM, Byrd R, Benowitz N, Liu E, Modin G (1991) Amiloride improves haemodynamics in patients with chronic congestive heart failure treated with chronic digoxin and diuretics. Cardiovasc Drugs Ther 5: 719–726
Waldorff S, Buch H (1979) Canrenoate — a spironolactone metabolite. Acute cardiac effects in digitalized patients. Eur J Cardiol 10: 143–149
Nicholls MG, Espiner EA, Hughes H, Rogers T (1976) Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure. Br Heart J 38: 1025–1030
Millar JA, Fraser R, Mason P, Leckie B, Cumming AMM, Robertson JIS (1984) Metabolic effects of high dose amiloride and spironolactone: a comparative study in normal subjects. Br J Clin Pharmacol 18: 369–375
Lefer AM, Sayers G (1964) Antagonism of the inotropic action of ouabain by aldosterone. Am J Physiol 208: 649–654
Appel WC, Vincenzi FF (1973) Positive inotropic effect of cardiotonic steroids: differential antagonism by aldosterone. J Pharmacol Exp Ther 187: 112–120
Debetto P, Luciani S, Tessari M, Floreani M, Carpenedo F (1989) Inhibition of Na+ Ca2+ exchange by amiloride acting from opposite sides of cardiac sarcolemma. Biochem Pharmacol 38: 1137–1145
Floreani M, Luciani SS (1984) Amiloride: relationship between cardiac effects and inhibition of Na+/Ca+ exchange. Eur J Pharmacol 105: 317–322
Waldorff S, Andersen JD, Heeboll-Nielsen N, Nielsen OG, Moltke E, Sorensen U, Steiness E (1987) Spironolactone-induced changes in digoxin kinetics. Clin Pharmacol Ther 24: 162–167
Stern HC, Matthews JH, Belz GG (1984) Influence of dihydralazine induced afterload reduction on systolic time intervals and echocardiography in healthy subjects. Br Heart J 52: 435–439
Hollander M, Wolf AD (1973) Nonparametric statistical methods. Wiley, New York, pp 138–153
Steyn AGW, Smit CF, Du Toit SHC (1989) Moderne Statistiek vir die Praktyk. Van Schaik, Pretoria, pp 504–508
Lewis RP, Rittgers SE, Forester WF, Boudoulas H (1977) A critical review of systolic time intervals. Circulation 56: 146–158
Yeh BK, Chiang BN, Sung P-K (1976) Antiarrhythmic activity of potassium canrenoate in man. Am Heart J 92: 308–314
Weis M, Sziegoleit W, Fahr A, Förster W (1983) Rapid achievement of a serum concentration plateau of digoxin through controlled infusion. Eur J Clin Pharmacol 25: 455–457
Buch J, Egeblad H, Hansen PB, Kjaergard H, Waldorff S, Steiness E (1980) Correlation between changes in systolic time intervals and left ventricular end-diastolic diameter after preload reduction. Br Heart J 44: 668–671
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Richter, J.P., De Sommers, K., Snyman, J.R. et al. The acute effects of amiloride and potassium canrenoate on digoxin-induced positive inotropism in healthy volunteers. Eur J Clin Pharmacol 45, 195–196 (1993). https://doi.org/10.1007/BF00315506
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00315506