Summary
Acetyl-L-carnitine 1.5 g and 3.0 g was administered as three divided doses on each of two occasions to 24 people with varying renal failure (creatinine clearance 127 – 8 ml·min−1). Plasma and urinary concentrations of total-L-carnitine, free (non-esterified) carnitine, short-chain esters and acetyl-L-carnitine were measured.
The baseline (pre-study) concentrations of all four substances were related to renal function. Patients whose creatinine clearance was below about 30–40 ml·min−1 were had the highest concentrations.
Renal elimination of all four substances was related to dose and to renal function. There was evidence for dose-related elimination, with greater elimination of the larger dose.
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Kelly, J.G., Hunt, S., Doyle, G.D. et al. Pharmacokinetics of oral acetyl-L-carnitine in renal impairment. Eur J Clin Pharmacol 38, 309–312 (1990). https://doi.org/10.1007/BF00315038
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DOI: https://doi.org/10.1007/BF00315038