Summary
Blood pressures and plasma atrial natriuretic peptide (ANP) concentrations have been measured in venous and intracardiac sites in 11 patients (10 men and 1 woman) given cardiac transplants.
The mean plasma ANP level was 214.4 pg·ml−1 in the superior veina cava and 281 pg·ml−1 in the right atrium. This significantly higher level was maintained in the right ventricle (269) and in the pulmonary artery (295). The level in controls was 25 pg·ml−1. Intra cardiac and mean arterial pressures were in normal range in all patients, and there was no correlation between plasma ANP level and intracardiac pressure.
The data suggest that in cardiac transplant patients right atrial pressure does not have a primary role in releasing ANP. The transplanted heart is denervated and remains so for many months after operation, thus suggesting that innervation is not obligatory for ANP secretion. Further studies are required to determine the relative contribution of donor and recipient atrial tissues to ANP secretion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bie P, Wang BC, Leadley JM-RJ, Goetzk L (1988) Haemodynamic and renal effects of low-dose infusions of atrial peptide in awake dogs. Am J Physiol 254: R161-R169
Atlas SA, Kleinert HD, Camargo MJ (1984) Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide. Nature 309: 709–719
Bolli P, Mieller FB, Linder L, Raine AEG, Resink TJ (1987) The vasodilator potency of atrial natriuretic peptide in man. Circulation 75: 221–228
Maki M, Tagayanagi R, Misono KS, Pandey KN, Tibbets C, Inagami T (1984) Structure of rat atrial natriuretic factor precurseur deduced from CON A sequence. Nature 309: 722–724
Raine AEG, Erne P, Burgisser E, Muller FB, Bolli P, Burkart F, Buhler FR (1986) Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. N Engl J Med 315: 533–537
Oikawa S, Imai M, Heno A (1984) Cloning and sequence analysis of C.DNA encoding a precursor for human atrial natriuretic polypeptide. Nature 309: 724–726
Zukowska-Grojec Z, Haass M, Kopin IJ, Zamir N (1986) Interactions of atrial natriuretic peptide with the sympathetic and endocrine systems in the pithed rat. J Pharmacol Exp Ther 239: 480–487
Schiebinger RJ, Baker MZ, Linden J (1987) Effect of adrenergic and muscarinic cholinergic agonists on atrial natriuretic peptide secretion by isolated rat atria. J Clin Invest 3: 1687–1691
Schiebinger RJ, Linden J (1986) The influence of resting tension on immuno-reactive ANP secretion. Circ Res 59: 105–109
Deray G, Maistre G, Cacoub P, Cabrol A, Rottembourg J, Cabrol C (1988) Plasma level of atrial natriuretic peptide in patients with artificial heart. Eur J Pharmacol 34: 91–93
Singer DRJ, Buckley MG, Mac Gregor GA, Khagani A, Banner NA, Yacoub MH (1986) Raised concentrations of plasma atrial natriuretic peptides in cardiac transplant recipients. Br Med J 293: 1391–1392
Myers BD, Peterson C, Molina C, Tomlanovich JS, Newton LD, Nitkin R, Sandler H, Murad F (1988) Role of cardiac atrial in the human renal response to changing plasma volume. Am J Physiol 254: F562-F573
Richard AM, Cleland JGF, Tonolo G, McIntyre GD, Leckie BJ, Dargie HJ, Ball SG, Robertson JIS (1986) Plasma alpha natriuretic peptide in cardiac impairment. Br Med J 293: 409–412
Rodeheffer RJ, Tanaka I, Imada T, Hollister AS, Robertson D, Inagami T (1986) Atrial pressure and secretion of atrial natriuretic factor into the human central circulation. IACC 8: 18–26
Sato F, Kamoi K, Wakiya Y, Ozawa T, Arai O, Ishibashi M, Yamaji T (1986) Relationship between plasma atrial natriuretic peptide levels and atrial pressure in man. J Clin Endocrinol Metab 63: 823–827
Drieu L, Rainfray M, Cabrol C, Ardaillou R (1986) Vasopressin aldosterone and renin response to volume depletion in heart-transplant recipients. Clin Sci 70: 233–241
Crozier IG, Nicholls MG, Ikram H, Espiner EA, Yandle TG, Siegfried J (1986) Atrial natriuretic peptide in humans. Production and clearance by various tissues. Hypertension 8 [Suppl 2]: 11–15
Luft CF, Lang RE, Aronoff GR, Ruskoaho H, Toth M, Ganten D, Sterzel G, Unger T (1985) Atriopeptin III kinetics and pharmacodynamics in normal and in anephric rats. J Pharmacol Exp Ther 236: 416–418
Zelis R, Flaim SF (1982) Alterations in vasomotor tone in congestive heart failure. Prog Cardiovasc Dis 24: 437–459
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Deray, G., Maistre, G., Desruenne, M. et al. Atrial natriuretic peptide level and intracardiac pressure in cardiac transplant recipients. Eur J Clin Pharmacol 38, 219–221 (1990). https://doi.org/10.1007/BF00315019
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00315019