Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration

Summary

Twelve children 1–5 y old were randomly assigned to receive midazolam 0.2 mg·kg−1 either by the intravenous (IV) or intranasal (IN) routes.

After IN administration the rapid onset of absorption was observed (tmax 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.4 h IV). After IN administration the apparent plasma clearance and volume of distribution were about twice as high as after IV administration.

The results are consistent with an estimated mean bioavailability of 55%.

This is a preview of subscription content, access via your institution.

References

  1. Allonen H, Ziegler G, Klotz U (1981) Midazolam kinetics. Clin Pharmacol Ther 30: 653–661

    Google Scholar 

  2. Bornemann LD, Min BH, Crews T, Rees MMC, Blumenthal HP, Colburn WA, Patel IH (1985) Dose dependent pharmacokinetics of midazolam. Eur J Clin Pharmacol 29: 91–95

    Google Scholar 

  3. Cole WHJ (1982) Midazolam in paediatric anaesthesia. Anaesth Intens Care 10: 36–39

    Google Scholar 

  4. D'Athis P (1988) Programme TRIOMPHE — traitement intéractif ordonné des modèles pharmacologiques élémentaires. Dijon: Département d'informatique médicale, Hôpital du Bocage

    Google Scholar 

  5. Gibaldi (1977) Biopharmaceutics and clinical pharmacokinetics, 2. ed. Lea and Febiger, Philadelphia

    Google Scholar 

  6. Holazo AA, Winkler MB, Patel IH (1988) Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics. J Clin Pharmacol 28: 1040–1045

    Google Scholar 

  7. Payne K, Mattheyse FJ, Liebenberg D, Dawes T (1989) The pharmacokinetics of midazolam in paediatric patients. Eur J Clin Pharmacol 37: 267–272

    Google Scholar 

  8. Reves JG, Fragen RJ, Vinik R, Greenblatt DJ (1985) Midazolam: Pharmacology and uses. Anaesthesiology 62: 310–324

    Google Scholar 

  9. Rita L, Seleny FL, Mazurek A, Rabins S (1985) Intramuscular midazolam for pediatric preanesthetic sedation: a double-blind controlled study with morphine. Anaesthesiology 63: 528–531

    Google Scholar 

  10. Saint-Maurice C, Meistelman C, Rey E, Estève C, de Lauture D, Olive G (1986) The pharmacokinetics of rectal midazolam for premedication in children. Anaesthesiology 65: 536–538

    Google Scholar 

  11. Slover R, Dedo W, Schlesinger T, Mattison R (1990) Use of intranasal midazolam in preschool children. Anaesth Analg 70: S377

  12. Smith MT, Eadie MJ, O'Rourke Brophy T (1981) The pharmacokinetics of midazolam in man. Eur J Clin Pharmacol 19: 271–278

    Google Scholar 

  13. Walbergh EJ, Eckert J (1989) Pharmacokinetics of intravenous (IV) and intranasal (IN) midazolam in children. Anaesthesiology 71: Abstract 1066

    Google Scholar 

  14. Wilton NCT, Leigh J, Rosen DR, Pandit UA (1988) Preanesthetic sedation of preschool children using intransal midazolam. Anaesthesiology 69: 972–975

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rey, E., Delaunay, L., Pons, G. et al. Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration. Eur J Clin Pharmacol 41, 355–357 (1991). https://doi.org/10.1007/BF00314967

Download citation

Key words

  • Midazolam
  • pharmacokinetics
  • intranasal
  • intravenous
  • children
  • bioavailability