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Differential cardiovascular effects of propranolol, atenolol, and pindolol measured by impedance cardiography

European Journal of Clinical Pharmacology volume 42, pages 47–53 (1992)Cite this article

Summary

We have evaluated Sramek's method of impedance cardiography as a non-invasive way of detecting the cardiovascular effects of drugs. We made cardiovascular measurements using the method during passive tilting and exercise 2 h after the oral administration of atenolol (50 and 100 mg), propranolol (40 and 80 mg), pindolol (5 and 10 mg), and placebo in seven separate studies involving eight healthy male volunteers.

Equivalent doses of the pure antagonists atenolol (β1) and propranolol (β1, β2) produced similar reductions in heart rate, systolic blood pressure, and cardiac index, and increases in stroke volume and total peripheral resistance, particularly during exercise. In contrast the partial agonist pindolol produced increases in heart rate and cardiac index, and reductions in peripheral resistance at rest. During passive tilting and exercise pindolol reduced heart rate, but cardiac output and total peripheral resistance were unchanged except at the highest levels of exercise.

The similar cardiovascular effects of atenolol and propranolol, but differing effects of pindolol, are consistent with reports using other methods of measurement. This suggests that impedance cardiography may have a place in the non-invasive assessment of the cardiovascular effects of drugs.

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Affiliations

  1. Division of Pharmacological Sciences and Toxicology, United Medical and Dental Schools (St Thomas' Campus), London, UK

    S. H. L. Thomas, R. C. Cooper, M. Ekwuru, S. Fletcher, J. Gilbody, T. S. Husseyin, M. Ishaque, R. Jagathesan, G. Reddy & S. E. Smith

  2. Wolfson Unit Department of Clinical Pharmacology, University of Newcastle upon Tyne, Claremont Place, NE1 4LP, Newcastle upon Tyne, UK

    S. H. L. Thomas

Authors
  1. S. H. L. Thomas
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  2. R. C. Cooper
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  3. M. Ekwuru
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  4. S. Fletcher
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  5. J. Gilbody
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  6. T. S. Husseyin
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  7. M. Ishaque
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  8. R. Jagathesan
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  9. G. Reddy
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  10. S. E. Smith
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Thomas, S.H.L., Cooper, R.C., Ekwuru, M. et al. Differential cardiovascular effects of propranolol, atenolol, and pindolol measured by impedance cardiography. Eur J Clin Pharmacol 42, 47–53 (1992). https://doi.org/10.1007/BF00314919

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  • DOI: https://doi.org/10.1007/BF00314919

Key words

  • Atenolol
  • Propranolol
  • Pindolol
  • transthoracic electrical bioimpedance
  • cardiac output
  • healthy volunteers