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Gene activation during immune reaction

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Summary

In cell-free systems the addition of antigen stimulates the synthesis of informational RNA (i-RNA) which exhibits the following properties: It codes for the entire antibody molecule, it codes for the synthesis of regulator protein which initiates transcription of i-RNA with the correspondent informational content from DNA, it is a template for an an i-RNA dependent RNA polymerase, it is a template for an i-RNA dependent reverse transcriptase. The i-RNA may exist in a state of latency in cells. The product of reverse transcription of i-RNA is i-DNA which can be used to transcribe further i-RNA of the same specificity. Similar to i-DNA is an extracellular DNA which codes also for antibody and from which i-RNA can be transcribed. The data presented are summarized in a scheme of the flow of information during immunological reactions.

It could be shown that there exist three different types of extrachromosomally synthesized molecules — i-RNA, i-DNA and extracellular DNA — which bear immunological specific information. These extrachromosomal states of information may be relevant for the generation of antibody diversity.

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Abbreviations

i-RNA:

informational RNA

i-DNA:

informational DNA

AAP:

antibody analogous product

BPoFlys:

benzoyl-penicilloyl-formyl-l-lysine

HSV:

Herpes simplex virus

HBs:

Hepatitis virus B, surface antigen

HBsad :

Hepatitis virus B, surface antigen, subtype ad

HBsay :

hepatitis virus B, surface antigen, subtype ay

PPD:

purified protein derivative of tuberculine

i-RNARk :

i-RNA decoding for antibody against Rk

i-RNAR5 :

i-RNA coding for antibody against R5

R5:

receptor particle for phage T5, derived from E. coli

Rk:

receptor particle for phage kappa, derived from Serratia marcescens

SDS:

sodium dodecyl sulfate

PBS:

phosphate buffered saline

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Authors and Affiliations

  1. Institut für Hygiene und Medizinische Mikrobiologie der Universität Bern, Friedbühlstrasse 51, CH-3010, Bern, Switzerland

    D. Jachertz

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Jachertz, D. Gene activation during immune reaction. Mol Cell Biochem 24, 93–126 (1979). https://doi.org/10.1007/BF00314890

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