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Inhibition of carnitine palmitoyltransferase (CPT) by chlorpromazine in muscle of patients with CPT deficiency

Journal of Neurology volume 236, pages 251–252 (1989)Cite this article

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References

  1. Luxnat M, Galla HJ (1986) Partition of chlorpromazine into lipid bilayer membranes: the effect of membrane structure and composition. Biochim Biophys Acta 856:274–282

    Google Scholar 

  2. McGarry JD, Leatherman GF, Foster DW (1978) Carnitine palmitoyltransferase I: the site of inhibition of hepatic fatty acid oxidation by malonyl-CoA. J Biol Chem 253:4128–4136

    Google Scholar 

  3. Reuschenbach C, Zierz S (1988) Mutant carnitine palmitoyltransferase associated with myoadenylate deaminase deficiency in skeletal muscle. J Pediatr 12:600–603

    Google Scholar 

  4. Vamecq J (1987) Chlorpromazine and carnitine-dependency of rat liver peroxisomal β-oxidation of long-chain fatty acids. Biochem J 241:783–781

    Google Scholar 

  5. Yamaguchi T, Watanabe S, Kimoto E (1985) ESP spectral changes induced by chlorpromazine in spin labeled erythrocyte ghost membranes. Biochim Biophys Acta 820:157–164

    Google Scholar 

  6. Zierz S, Engel AG (1985) Regulatory properties of a mutant carnitine palmitoyltransferase in human skeletal muscle. Eur J Biochem 149:207–214

    Google Scholar 

  7. Zierz S, Engel AG (1987) Different sites of inhibition of carnitine palmitoyltransferase by malonyl-CoA, and by acetyl-CoA and CoA, in human skeletal muscle. Biochem J 245:205–209

    Google Scholar 

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Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Straße 25, D-5300, Bonn, Federal Republic of Germany

    S. Zierz & S. Neumann-Schmidt

Authors
  1. S. Zierz
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  2. S. Neumann-Schmidt
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Zierz, S., Neumann-Schmidt, S. Inhibition of carnitine palmitoyltransferase (CPT) by chlorpromazine in muscle of patients with CPT deficiency. J Neurol 236, 251–252 (1989). https://doi.org/10.1007/BF00314510

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  • DOI: https://doi.org/10.1007/BF00314510

Keywords

  • Public Health
  • Carnitine
  • Chlorpromazine
  • Carnitine Palmitoyltransferase