Journal of Neurology

, Volume 236, Issue 2, pp 120–122 | Cite as

Effect of cannabinoids on spasticity and ataxia in multiple sclerosis

  • H. -M. Meinck
  • P. W. Schönle
  • B. Conrad
Short Communications


The chronic motor handicaps of a 30-year-old multiple sclerosis patient acutely improved while he smoked a marihuana cigarette. This effect was quantitatively assessed by means of clinical rating, electromyographic investigation of the leg flexor reflexes and electromagnetic recording of the hand action tremor. It is concluded that cannabinoids may have powerful beneficial effects on both spasticity and ataxia that warrant further evaluation.

Key words

Multiple sclerosis Spasticity Ataxia Cannabinoids Flexor reflex 


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  1. 1.
    Boyd ES, Meritt DA (1965) Effects of a tetrahydrocannabinol derivative on some motor systems in the cat. Arch Int Pharmacodyn Ther 153:1–12Google Scholar
  2. 2.
    Čapek R, Esplin B (1976) Effects of Δ9-tetrahydrocannabinol on the homosynaptic depression in the spinal monosynaptic pathway: implications for transmitter dynamics in the primary afferents. In: Nahas GG, Paton WDM, Idäänpään-Heikkila JE (eds) Marihuana — chemistry, biochemistry, and cellular effects. Springer, New York Berlin Heidelberg, pp 385–395Google Scholar
  3. 3.
    Chan-Palay V (1984) Purkinje cells of the cerebellum: localization and function of multiple neuroactive substances. Exp Brain Res [Suppl] 9:129–144Google Scholar
  4. 4.
    Clifford DB (1983) Tetrahydrocannabinol for tremor in multiple sclerosis. Ann Neurol 13:669–671Google Scholar
  5. 5.
    Domino EF (1976) Effects of Δ9-tetrahydrocannabinol and cannabinol on rat brain acetylcholine. In: Nahas GG, Paton WDM, Idäänpään-Heikkila JE (eds) Marihuana — chemistry biochemistry and cellular effects. Springer, New York Berlin Heidelberg, pp 407–413Google Scholar
  6. 6.
    Dunn M, Davis R (1974) The perceived effects of marijuana on spinal cord injured males. Paraplegia 12:175Google Scholar
  7. 7.
    Gilbert PE (1981) A comparison of THC, nantradol, nabilone, and morphine in the chronic spinal dog. J Clin Pharmacol 21:311–319Google Scholar
  8. 8.
    Ho BT, Johnson KM (1976) Sites of neurochemical action of Δ9-tetrahydrocannabinol: interaction with reserpine. In: Nahas GG, Paton WDM, Idäänpään-Heikkila JE (eds) Marihuana — chemistry, biochemistry, and cellular effects. Springer, New York Berlin Heidelberg, pp 367–381Google Scholar
  9. 9.
    Howes JF, Osgood PF (1976) Cannabinoids and the inhibition of prostaglandin synthesis. In: Nahas GG, Paton WDM, Idäänpään-Heikkila JE (eds) Marihuana — chemistry, biochemistry, and cellular effects. Springer, New York Berlin Heidelberg, pp 415–424Google Scholar
  10. 10.
    Jurna J (1984) Depression of nociceptive sensory activity in the rat spinal cord due to the intrathecal administration of drugs: effects of diazepam. Neurosurgery 15:917–920Google Scholar
  11. 11.
    Malec J, Harvey RF, Cayner JJ (1982) Cannabis effect on spasticity in spinal cord injury. Arch Phys Med Rehabil 63:116–118Google Scholar
  12. 12.
    Meinck H-M, Conrad B (1986) Neuropharmacological investigations in the stiff-man syndrome. J Neurol 233:340–347Google Scholar
  13. 13.
    Meinck H-M, Benecke R, Conrad B (1985) Cutaneo-muscular control in health and disease: possible implications on spasticity. In: Struppler A, Weindl A (eds) Electromyography and evoked potentials, theories and applications. Advances in applied neurological sciences, vol 1. Springer, New York Berlin Heidelberg, pp 75–83Google Scholar
  14. 14.
    Petro DJ, Ellenberger C (1981) Treatment of human spasticity with Δ9-tetrahydrocannabinol. J Clin Pharmacol 21:413–416Google Scholar
  15. 15.
    Schönle PW, Gräbe K, Wenig P, Höhne J, Schrader J, Conrad B (1987) Electromagnetic articulography — use of alternating magnetic fields for tracking movements of multiple points inside and outside the vocal tract. Brain Lang 31:26–35Google Scholar
  16. 16.
    Segal M (1986) Cannabinoids and analgesia. In: Mechoulam R (ed) Cannabinoids as therapeutic agents. CRC Press, Boca Raton. Fla, pp 105–120Google Scholar
  17. 17.
    Tramposch A, Sangdee C, Franz DN, Karler R, Turkanis SA (1981) Cannabinoid-induced enhancement and depression of cat monosynaptic reflexes. Neuropharmacology 20:617–621Google Scholar
  18. 18.
    Turkanis SA, Karler R (1983) Effects of Δ9-tetrahydrocannabinol on cat spinal motoneurons. Brain Res 288:283–287Google Scholar
  19. 19.
    Willer JC, Bussel B (1980) Evidence for a direct spinal mechanism in morphine-induced inhibition of nociceptive reflexes in humans. Brain Res 187:212–215Google Scholar
  20. 20.
    Yaksh TL (1981) The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the rat. J Clin Pharmacol 21:334–340Google Scholar
  21. 21.
    Yaksh TL, Reddy SVR (1981) Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen. Anesthesiology 54:451–467Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. -M. Meinck
    • 1
  • P. W. Schönle
    • 1
  • B. Conrad
    • 1
  1. 1.Department of Clinical NeurophysiologyUniversity of GöttingenFederal Republic of Germany

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