Summary
The optically evoked blink reflex (BR) was recorded in 30 patients (20 females, 10 males) with primary acute optic neuritis (ON) unassociated with other CNS disorders. The reflex was studied in the acute stage between the 1st and 6th day after onset, during the 1st month following the acute stage once a week, and then 2 and 6 months later. In patients in whom a relapse occurred, the programme was restarted from the beginning. Control values were taken from prior investigations in 50 healthy subjects. In the acute stage differences in the amplitudes were present in 26 patients, but the latencies remained within normal limits. Six patients (20%) developed multiple sclerosis during the 5-year follow-up until December 1985. In these cases the optic BR showed increased latencies and decreased amplitudes. In patients without manifestation of multiple sclerosis the BR remained normal. In 7 patients cranial magnetic resonance imaging (MRI) was done. All patients with some abnormalities in the visual BR also had an abnormal MRI. The pattern-shift visual evoked potentials were abnormal in the acute stage of ON in 90%, and CSF abnormalities were found in 56.6%. In 4 patients (13%) the visual BR could not be evoked at all.
References
Brodal A (1981) Neurological anatomy in relation to clinical medicine, 3rd edn. Oxford University Press, New York Oxford
Chiappa KH (1983) Evoked potentials in clinical medicine. Raven Press, New York
Courville J (1966) The nucleus of the facial nerve: the relation between cellular groups and peripheral branches of the nerve. Brain Res 1:338–354
Levinsohn G (1904) Über Lidreflexe. Graefe's Arch Ophthalmol 59:391–423
Levinsohn G (1913) Der optische Blinkreflex. Z Gesamte Neurol Psychiatr 20:377–385
Malin J-P (1982) Der optisch evozierte Orbicularis-oculi-Reflex: Methodik, Normalwerte, Habituation. Z EEG-EMG 13:101–107
Malin J-P (1986) Methodik und Stellenwert der Untersuchung des optisch evozierten Blinkreflexes in der Hirnstammdiagnostik. In: Lowitzsch K (ed) Hirnstammreflexe. Methodik und klinische Anwendung. Thieme, Stuttgart New York
Malin J-P, Müller H, Patzold U (1982) The optically evoked blink reflex in the diagnosis of multiple sclerosis. In: Courjon J, Mauguiere F, Revol M (eds) Clinical applications of evoked potentials in neurology. Raven Press, New York
Ongerboer de Visser BW (1983) Anatomical and functional organization of reflexes involving the trigeminal system in man: jaw reflex, blink reflex, corneal reflex, and exteroceptive suppression. In: Desmedt JE (ed) Motor control mechanisms in health and disease. Raven Press, New York
Panneton WM, Martin GF (1978) Midbrain projections to the facial nucleus in the opossum. Brain Res 145:355–359
Rushworth G (1962) Observations on blink reflexes. J Neurol Neurosurg Psychiatry 25:93–108
Takeuchi Y, Nakano K, Kemura M, Matsuda K (1979) Mesencephalic and pontine afferent fiber system to the facial nucleus in the cat: a study using the horseradish peroxidase and silver impregnation techniques. Exp Neurol 66:330–342
Wurster U, Patzold U, Haas J (1984) Cerebrospinal fluid findings in isolated optic neuritis compared to multiple sclerosis. In: Gonsette RE, Delmotte P (eds) Immunological and clinical aspects of multiple sclerosis. MTP Press, Lancaster Boston
Yates SK, Brown WF (1981) Light-stimulus evoked blink reflex: methods, normal values, relation to other blink reflexes, and observations in multiple sclerosis. Neurology 31:272–281
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Malin, J.P. Visual evoked blink reflex in optic neuritis. J Neurol 235, 49–52 (1987). https://doi.org/10.1007/BF00314199
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DOI: https://doi.org/10.1007/BF00314199