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Serum creatine kinase B subunit levels in neurogenic atrophies

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Summary

This study is an attempt to determine the creatine kinase B (CK-B) subunit levels in neurogenic atrophies. A group of 69 patients was studied and the results were compared with those in a group of 32 patients with muscle disease. The results showed that the CK-B levels are considerably higher in patients with amyotrophic lateral sclerosis (P<0.001) and peroneal muscular atrophy (P<0.001). Further studies in the various subgroups of neurogenic atrophies showed that, regardless of the nosological entity, the CK-B activity is considerably higher: (1) in the “widespread” as opposed to “limited” forms (P<0.001); (2) in the “chronic” than in the “acute” neurogenic atrophies (P<0.001); and (3) in the “active” as opposed to “residual” forms (P<0.02). It is suggested that the increase of CK-B in neurogenic atrophies is a strong indication of an active regeneration process in the denervated muscle.

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Authors and Affiliations

  1. Institute of Biological Research, National Hellenic Research Foundation, Athens, Greece

    E. Jockers-Wretou

  2. Department of Neurology, Athens University, 74, Vass. Sofias Aven., 11528, Athens, Greece

    D. Vassilopoulos

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  1. E. Jockers-Wretou
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  2. D. Vassilopoulos
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Jockers-Wretou, E., Vassilopoulos, D. Serum creatine kinase B subunit levels in neurogenic atrophies. J Neurol 232, 236–239 (1985). https://doi.org/10.1007/BF00313786

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  • DOI: https://doi.org/10.1007/BF00313786

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