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Ventricular somatostatin-like immunoreactivity in patients with basal ganglia disease

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Summary

The concentrations of somatostatin-like immunoreactivity (SLI) in lateral ventricular fluid of patients with extrapyramidal motor disease were determined by specific radio-immunoassay. Mean SLI levels were significantly lower in patients with Parkinson's disease (mean ± SEM); 42.9±2.9 fmol/ml) and in patients with dystonic syndromes (39.4±3.2) than in patients with benign essential tremor (65.3±9.7). The lowest levels were found in patients with athetosis (34.7±5.4). In parkinsonian patients somatostatin levels correlated with the degree of akinesia, rigidity and autonomic disturbances.

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Authors and Affiliations

  1. Department of Neurology and Clinical Neurophysiology, University of Freiburg, Hansastr. 9, D-7800, Freiburg, Germany

    H. Cramer, A. Wolf & K. Rissler

  2. Department of Stereotaxy and Neuronuclear Medicine, University of Freiburg, Hansastr. 9, D-7800, Freiburg, Germany

    K. Weigel & C. Ostertag

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  1. H. Cramer
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  2. A. Wolf
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  3. K. Rissler
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  4. K. Weigel
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  5. C. Ostertag
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Cramer, H., Wolf, A., Rissler, K. et al. Ventricular somatostatin-like immunoreactivity in patients with basal ganglia disease. J Neurol 232, 219–222 (1985). https://doi.org/10.1007/BF00313783

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  • DOI: https://doi.org/10.1007/BF00313783

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