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Methodik und Auswertung visuell evozierter EEG-Potentiale bei Verdacht auf multiple Sklerose

Methods and evaluation of visually evoked EEG potentials in cases of suspected multiple sclerosis

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Summary

In multiple sclerosis, average EEG potentials which are monocularly evoked by checkerboard pattern reversal frequently show increased latencies of the dominant, occipitally positive peak (more than 110 ms), and latency differences of more than 6–7 ms between responses to right and left eye stimulation.

Fixation of the stimulus field at the lower border causes significantly longer latencies and smaller amplitudes than fixation at the upper border. With lower border fixation, the increase of response latency may suggest a reversal of response polarity in extreme cases. Central fixation often but not always results in responses similar to upper border fixation. In order to have minimal variability of the results, fixation of the stimulus field at the upper border is preferred over central fixation.

Zusammenfassung

Durch Schachbrettmusterinversion monoculär evozierte gemittelte EEG-Potentiale haben häufig bei multipler Sklerose verzögerte Latenzen der occipital positiven Welle (über 110 ms) und Latenzdifferenzen über 6–7 ms zwischen rechts-und linksäugiger Reizung.

Fixation des Stimulusfeldes am unteren Pol führt zu signifikant längeren Latenzen und geringeren Amplituden als Fixation am oberen Pol. Bei unterer Fixation kann die Verzögerung in extremen Fällen bis zu einer anscheinenden Polaritätsumkehr der gemittelten Potentiale gehen. Zentralfixation führt oft, aber nicht immer zu gemittelten Potentialen, die jenen bei oberer Polfixation ähneln. Fixation des Stimulusfeldes am oberen Pol ist daher der Zentralfixation vorzuziehen, um möglichst geringe Streuung der Ergebnisse zu erreichen.

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Unterstützt von Stiftung für wissenschaftliche Forschung Zürich und Schweizerischem Nationalfonds.

Stipendiat der Roche-Studienstiftung. Adresse: Draskoviceva 4 A, 4100 Zagreb, Jugoslawien.

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Lehmann, D., Mir, Z. Methodik und Auswertung visuell evozierter EEG-Potentiale bei Verdacht auf multiple Sklerose. J. Neurol. 213, 97–103 (1976). https://doi.org/10.1007/BF00313271

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  • DOI: https://doi.org/10.1007/BF00313271

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