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A genetic aspect of chromatin proteins of human brain tumors

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Summary

Electrophoretic analysis of chromatin proteins was performed on rat and human tissues. Species and organ specific patterns were demonstrated in them.

Twenty cases of human brain tumors were also analyzed and each tumor had typical phoretic patterns of chromatin. Proteins obtained from histologically similar tumors display similar electrophoretic patterns. As to the ratio of chromatin protein to DNA, no apparent differences between benign and malignant human brain tumors were observed.

Zusammenfassung

Elektrophoretische Analyse der Chromatin-Proteine bei der Ratte und in menschlichen Geweben. Dabei werden die Muster herausgearbeitet, die für die Species und das Organ spezifisch sind. Weiter werden 20 Fälle von menschlichen Hirntumoren untersucht und dabei gefunden, daß jeder Tumor ein typisches elektrophoretisches Chromatinmuster hatte. Die Proteine von histologisch ähnlichen Tumoren zeigen auch ähnliche elektrophoretische Muster. Beim Vergleich des Chromatin-Proteins mit der DNA stellte sich heraus, daß es keine eindeutigen Unterschiede zwischen gutartigen und bösartigen Hirntumoren beim Menschen gibt.

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Authors and Affiliations

  1. Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, 812, Fukuoka, Japan

    K. Fujii, K. Kitamura & Y. Tsubota

  2. Department of Neurosurgery, Asahikawa Medical School, Japan

    Y. Yonemasu

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  1. K. Fujii
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  2. Y. Yonemasu
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  3. K. Kitamura
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  4. Y. Tsubota
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Fujii, K., Yonemasu, Y., Kitamura, K. et al. A genetic aspect of chromatin proteins of human brain tumors. J. Neurol. 223, 23–34 (1980). https://doi.org/10.1007/BF00313137

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  • DOI: https://doi.org/10.1007/BF00313137

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