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A mobile group II intron of a naturally occurring rearranged mitochondrial genome in Kluyveromyces lactis

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Summary

Mitochondrial intron content is variable in the yeast Kluyveromyces lactis. Strains can be divided into three classes depending on the structure of the cytochrome oxidase subunit 1 (COX1) gene: (1) those containing intron K1 cox1.1, (2) those containing K1 cox1.2, 3 and 4 and, (3) those that contain all four introns. In addition, strains belonging to the first class (designated Type B strains), have an altered mitochondrial gene order relative to strains from classes (2) and (3) (Type A, Hardy et al. 1989). Crossing experiments reveal that K1 cox1.1 (a group II intron) transfers at high frequency (89%) to mitochondrial genomes lacking this intron. By contrast, the mobility of the remaining introns (all group I) is of the order of 7%.

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References

  • Augustin S, Muller MW, Schweyen RJ (1990) Nature 343:383–386

    Google Scholar 

  • Bianchi MM; Falcone C, Chen XJ, Wesolowski-Louvel M, Frontali L, Fukuhara H (1987) Curr Genet 12:185–192

    Google Scholar 

  • Bonitz SG, Coruzzi G, Thalenfeld BE, Tzagoloff A, Macino G (1980) J Biol Chem 255:11927–11941

    Google Scholar 

  • Brunner A, Coria R (1989) Yeast 5:209–218

    Google Scholar 

  • Clark-Walker GD (1989) Proc Natl Acad Sci USA 86:8847–8852

    Google Scholar 

  • Clark-Walker GD (1991) Int Rev Cytol (in press)

  • Das S, Hollenberg CP (1982) Curr Genet 6:123–128

    Google Scholar 

  • Dujon B, (1989) Gene 82:91–114

    Google Scholar 

  • Feinberg AP, Vogelstein B (1983) Anal Biochem 132:6–13

    Google Scholar 

  • Galeotti CL, (1981) PhD Thesis. Australian National University

  • Grivell LA (1990) Nature 344:110–111

    Google Scholar 

  • Hardy CM, Clark-Walker GD (1990) Yeast 6:403–410

    Google Scholar 

  • Hardy CM, Clark-Walker GD (1991). Curr Genet

  • Hardy CM, Galeotti CL, Clark-Walker GD (1989) Curr Genet 16:419–427

    Google Scholar 

  • Hoeben P, Clark-Walker GD (1986) Curr Genet 10:371–379

    Google Scholar 

  • Lambowitz AM (1989) Cell 56:323–326

    Google Scholar 

  • Macino C, Tzagoloff A (1979) J Biol Chem 254:4617–4623

    Google Scholar 

  • Maleszka R, Clark-Walker GD (1989) Curr Genet 16:429–432

    Google Scholar 

  • Meunier B, Tian GL, Macadre C, Slonimski PP, Lazowska J (1990) In: Quagliariello E, Papa S, Palmieri F, Saccone C (eds), Structure, function and biogenesis of energy transfer systems. Elsevier, Amsterdam, pp 169–174

    Google Scholar 

  • Michel F, Lang BF (1985) Nature 316:641–643

    Google Scholar 

  • Morl M, Schmelzer C (1990) Cell 60:629–636

    Google Scholar 

  • Morl M, Schmelzer C (1990) Cell 60:629–636

    Google Scholar 

  • Morl M, Schmelzer C (1990) Nucleic Acids Res 18:6545–6551

    Google Scholar 

  • Nobrega FG, Tzagoloff A (1980) J Biol Chem 255:9828–9837

    Google Scholar 

  • Reed KC, Mann DA (1985) Nucleic Acids Res 13:7207–7221

    Google Scholar 

  • Skelly PJ, Clark-Walker GD (1990) Mol Cell Biol 10:1530–1537

    Google Scholar 

  • Skelly PJ, Maleszka R (1991) Curr Genet 19:89–94

    Google Scholar 

  • Tingle M, Herman A, Halvorson HO (1968) Genetics 58:361–371

    Google Scholar 

  • Wenzlau JM, Saldanha RJ, Butow RA, Perlman PS (1989) Cell 56:421–430

    Google Scholar 

  • Xiong Y, Eickbush TH (1990) EMBO J 9:3353–3362

    Google Scholar 

  • Zinn AR, Butow RA (1985) Cell 40:887–895

    Google Scholar 

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Author notes

  1. P. J. Skelly

    Present address: Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, 02115, Boston, MA, USA

Authors and Affiliations

  1. Molecular and Population Genetics Group, Research School of Biological Sciences, Australian National University, GPO Box 475, 2601, Canberra, ACT, Australia

    P. J. Skelly, C. M. Hardy & G. D. Clark-Walker

Authors
  1. P. J. Skelly
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  2. C. M. Hardy
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  3. G. D. Clark-Walker
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Communicated by R. J. Schweyen

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Skelly, P.J., Hardy, C.M. & Clark-Walker, G.D. A mobile group II intron of a naturally occurring rearranged mitochondrial genome in Kluyveromyces lactis . Curr Genet 20, 115–120 (1991). https://doi.org/10.1007/BF00312773

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  • DOI: https://doi.org/10.1007/BF00312773

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