Abstract
Venous invasion as a prognostic factor was evaluated in 124 patients with colorectal cancer. By classifying the patients as having either negative to mild invasion or moderate to marked invasion, a significant correlation was found between the degree of venous invasion and clinicopathological variables such as lymphatic invasion, lymph node metastasis, liver metastasis, and DNA ploidy. Significantly more favorable survival was seen in those with a lower degree of vascular invasion; however, of the six prognosticators analyzed by Cox's proportional hazard model, the only significant factors were depth of invasion and DNA ploidy. Although venous invasion showed no significance, it is still considered a valuable prognostic indicator that is easy and economical to perform.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Talbot IC, Ritchie S, Leighton M, Hughes AO, Bussey HT, Morson BC (1980) The clinical significance of invasion of veins by rectal cancer. Br J Surg 67:439–442
Krasma MJ, Flancbaum L, Cody RP, Shneibaum S, Ari GB (1988) Vascular and neural invasion in colorectal carcinoma: incidence and prognostic significance. Cancer 61:1018–1023
Minsky BD, Mies C, Rich TA, Chaffey JT (1988) Potentially curative surgery of colon cancer: the influence of blood vessel invasion. J Clin Oncol 6:119–127
Dukes CE (1932) The classification of cancer of the rectum. J Pathol Bacteriol 35:323–332
Japanese Research Society for Cancer of the Colon and Rectum (1983) General rules for clinical and pathological studies on cancer of the colon, rectum and anus. Jpn J Surg 13:557–573
Schutte B, Reynders MMJ, Bosman FT, Blijham GH (1985) Flowcytometric determination of DNA ploidy level in nuclei isolated from paraffin-embedded tissue. Cytometry 6:26–30
Cole WH (1954) Precautions in the spread of cancer of the colon and rectum. Ann Surg 40:135–136
Burns FJ, Pfaff J Jr (1956) Vascular invasion in carcinoma of the colon and rectum. Am J Surg 92:704–709
Lui K, Enjoji K, Inokuchi K (1980) Venous permeation of colorectal carcinoma. Jpn J Surg 10:284–289
Konishi F (1983) Clinicopathological study of venous invasion in colorectal carcinoma (in Japanese with English abstract). Jpn J Gastroenterol 80:1599–1609
Talbot IC, Ritchie S, Leighton M, Hughes AO, Bussey HJ, Morson BC (1981) Invasion of veins by carcinoma of rectum: method of detection, histological features and significance. Histopathology 5:141–163
Phillips RK, Hittinger R, Blesovsky L, Fry JS, Fielding LP (1984) Large bowel cancer: surgical pathology and its relationship to survival. Br J Surg 71:604–610
Chapuis PH, Dent OF, Fisher R, Newland RC, Pheils MT, Smyth E, Colquhoun K (1985) A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer. Br J Surg 72:698–702
Willis RA (1932) The importance of venous invasion in the development of metastatic tumours in the liver. J Pathol Bacteriol 35:1489–1494
Jass JR, Love SB, Northover JM (1987) A new prognostic classification of rectal cancer. Lancet 1:1303–1306
Bloom AL, Gidding JC, Wilks CJ (1973) Factor on the vascular intima: Possible importance in hemostasis and thrombosis. Nature 241:217
Liotta LA (1984) Tumor invasion and metastases: Role of the basement membrane. Am J Pathol 117:339–348
Forster SJ, Talbot IC, Claiton IC, Critchley DR (1986). Tumor basement membrane laminin in adenocarcinoma of rectum: An immunohistochemical study of biological and clinical significance. Int J Cancer 37:813–817
Terranova VP, Hujanen ES, Loeb DM, Martin GR, Thornburg L, Glushko V (1986) Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells. Proc Natl Acad Sci USA 83:465–469
Armitage NC, Robins RA, Evans DF, Turner DR, Baldwin RW, Hardcastle DJ (1985) The influence of tumor cell DNA abnormalities on survival in colorectal cancer. Br J Surg 72:828–830
Kokal W, Sheibani K, Terz J, Harada K (1986) Tumor DNA content in the prognosis of colorectal carcinoma. JAMA 255:3123–3127
Tsuchiya A, Ando Y, Ishii Y, Yoshida T, Abe R (1992) Flow-cytometric analysis in Japanese colorectal cancer. A multivariate analysis. Eur J Surg Oncol 18:585–590
Bauer KD, Lincoln ST, Vera-Roman JM (1987) Prognostic implication of proliferative activity and DNA aneuploidy in colorectal adenocarcinoma. Lab Invest 57:329–335
Rognum TO, Thorud E, Lund E (1987) Survival of large bowel carcinoma patients with different DNA ploidy. Br J Cancer 56:633–636
Hasegawa H (1985) A microphotometric study on the nuclear DNA content in cells of human and experimental large intestine carcinomas (in Japanese with English abstract). Arch Jpn Chir 54:486–497
Tsujita K (1988) A study of the relationship between nuclear DNA content and pathological findings and prognosis in colorectal cancer (in Japanese with English abstract). J Jpn Soc Colo-proctol 41:760–768
Kosaka T, Kamata T, Ishida T, Kato M, Yamaguchi A, Yonemura Y, Miyazaki I (1987) Clinicopathological studies of nuclear DNA distribution in colorectal cancer (in Japanese with English abstract). J Jpn Surg Soc 88:1705–1709
Ori T, Baba S, Ozawa T (1988) Flowcytometric DNA analysis in colorectal cancers and its relationship to clinicopathological findings and prognosis (in Japanese). Jpn J Gastroenterol Surg 21:1081–1085
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tsuchiya, A., Ando, Y., Kikuchi, Y. et al. Venous invasion as a prognostic factor in colorectal cancer. Surg Today 25, 950–953 (1995). https://doi.org/10.1007/BF00312379
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00312379