Abstract
Hepatic circulation after hepatectomy was investigated in conscious dogs under fasting and feeding conditions. After a 40% hepatectomy, both the hepatic arterial and portal blood flow were measured simultaneously using ultrasonic transit time flowmeters. During fasting, the total hepatic blood flow (i.e., the sum of arterial and portal blood flow) changed in a biphasic pattern after hepatectomy. The first peak (517.9±42.7 ml/min; 130.1% of preoperative flow) was seen on the 1st postoperative day (POD) and the second peak (444.8±25.6 ml/min; 112.7% of preoperative flow) occurred on the 7th POD. The portal flow demonstrated the same biphasic changes as the total hepatic flow, although the hepatic arterial flow showed only the first peak. A heart rate analysis suggested that the first peak was probably due to hyperdynamic circulatory conditions, as has been previously reported. In addition, the existence of the second peak was established by the present study. The postprandial hepatic blood flow decreased during the first 2 weeks postoperatively, but exceeded the presurgical levels on PODs 21 and 28.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Moriura S, Nimura Y, Kato M, Sato T, Shionoya S (1990) Effect of acute portal hypertension by portal venous stenosis on systemic hemodynamics in dogs. Eur Surg Res 22:113–119
Yamamoto H, Nimura Y, Yasui A, Moriusa S, Kato M (1992) Hepatic hemodynamics after partial hepatic congestion in dogs. Eur Surg Res 24:169–11579
Benacerraf B, Bilbey D, Biozzi G, Halpern BN, Stiffel C (1957) The measurement of liver blood flow in partially hepatectomized rats. J Physiol 136:287–293
Aronsen KF, Ericsson B, Grundsell H, Nylander G, Ohlsson EG, Pihl B (1969) Disappearance rate of 133Xe from the liver following partial hepatectomy in dogs. Acta Chir Scand 135:511–514
Rice GC, Ryan CJ, Leiberman RT, Mathie E, McGhee E, Happer AM, Blumgart LH (1977) Measurement of liver blood flow in the rat using an 85krypton clearance technique. Br J Exp Path 58:236–242
Kahn D, Van Horn-Hickman R, Terblanche J (1984) Liver blood flow after partial hepatectomy in the pig. J Surg Res 37:290–294
Ohlsson EG, Rutherford RB, Haalebos M, Wagner HN, Zuidema GD (1969) The distribution of portal blood flow before and after hepatic resection in dogs. J Surg Res 9:657–663
Menyhart J, Simon L (1965) Circulatory events accompanying liver regeneration following partial hepatectomy. Acta Physiol Acad Scient Hung 30:169–174
Saba TM (1969) Liver blood flow and intravascular colloid clearance alteration following partial hepatectomy. J Reticuloendothel Soc 7:406–417
Richardson PDI, Witherington PG (1981) Liver blood flow. Gastroenterology 81:159–173
Takagi T, Naruse S, Shionoya S (1988) Postprandial celiac and superior mesenteric blood flow in conscious dogs. Am J Physiol 255:G522-G528
Kato M, Naruse S, Takagi T, Shionoya S (1989) Postprandial gastric flow in conscious dogs. Am J Physiol 256:G111-G117
Yamazaki O, Sakai K, Kinoshita H, Hirohashi K, Tsuji Y, Suzuki N, Inoue T (1986) Measurement of the portal blood flow in man by continuous local thermodilution method: 2. Portal hemodynamics before and after hepatectomy (in Japanese with English abstract). Jpn J Gastroenterol 87:743–753
Cruise JL, Houck KA, Michalopoulos G (1988) Early events in the regulation of hepatocyte DNA synthesis: The role of alpha-adrenergic stimulation. Scand J Gastroenterol Supp 23:19–30
Leffert HL, Koch KS, Lad PJ, Shapiro IP, Skelly H, de Hemptinne B (1987) Hepatocyte regeneration and differentiation. In: Arias IM, Jakoby WB, Popper H, Schachter D, Shfriz D (eds) The liver: biology and pathobiology, 2nd edn. Raven, New York, pp 833–850
Chamuleau RAFM, Bosman DK (1988) Liver regeneration. Hepatogastroenterology 35:309–312
Wilmore DW (1991) Homeostasis bodily changes in trauma and surgery. In: Sabiston Jr DC (ed) Textbook of surgery, 14th edn. Saunders, Philadelphia, pp 19–33
Hirano T, Manabe T, Yamaki K, Tobe T (1990) Endocrine and exocrine pancreas and gut hormones in partially hepatectomized dogs. Surg Res Commun 8:1–6
Chou CC, Magino MJ, Sawmiller DR (1984) Gastrointestinal hormones and intestinal blood flow. In: Shepherd AP, Granger DN (eds) Physiology of the intestinal circulation. Raven, New York, pp 121–130
Laut WW (1983) Relationship between hepatic blood flow and overall metabolism: the hepatic arterial buffer response. Fed Proc 42:1662–1666
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sato, T., Yasui, A., Kondo, S. et al. Changes in liver blood flow after hepatectomy in conscious dogs. Surg Today 26, 688–693 (1996). https://doi.org/10.1007/BF00312085
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00312085