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The effects of intravenously infused catecholamines on hepatic blood flow in conscious dogs with experimental obstructive jaundice

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Abstract

This study was conducted to examine how the effects of dopamine and dobutamine on hepatic blood flow were influenced by obstructive jaundice in a conscious canine model. Prior to biliary obstruction, portal venous blood flow (PVF) increased in response to the infusion of either dopamine or dobutamine: dopamine infused at 8 μg/kg per min produced an increase of 19±0% in PVF, while dobutamine infused at 16 μg/kg per min produced an increase of 30±2%. Although hepatic arterial blood flow (HAF) decreased dose-dependently in response to the infusion of dopamine, no significant change was observed in HAF in response to any dose of dobutamine. Obstructive jaundice attenuated or completely abolished the PVF-increasing effect of dopamine, whereas it did not significantly alter the effect of dobutamine on hepatic blood flow. In dogs with obstructive jaundice, dopamine at 16 μg/kg per min produced a decrease of 17±3% in PVF. These findings suggest that dobutamine is more effective than dopamine for increasing hepatic blood flow in patients with obstructive jaundice.

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Authors and Affiliations

  1. First Department of Surgery, Nagoya University School of Medicine, 65 Tsurumaicho, Showa-ku, 466, Nagoya, Japan

    Yoshimi Kitagawa, Yuji Nimura, Hiroshi Kanda, Toshio Uematsu, Satoaki Kamiya, Yuichi Machiki & Tomohito Watanabe

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  1. Yoshimi Kitagawa
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  2. Yuji Nimura
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  3. Hiroshi Kanda
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  4. Toshio Uematsu
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  5. Satoaki Kamiya
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  6. Yuichi Machiki
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  7. Tomohito Watanabe
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Kitagawa, Y., Nimura, Y., Kanda, H. et al. The effects of intravenously infused catecholamines on hepatic blood flow in conscious dogs with experimental obstructive jaundice. Surg Today 26, 21–28 (1996). https://doi.org/10.1007/BF00311987

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  • DOI: https://doi.org/10.1007/BF00311987

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