Abstract
A 66-year-old woman was diagnosed as having lupoid hepatitis due to the presence of hypergammaglobulinemia, lupus erythematosus cells, and positivity for antinuclear, anti-DNA, and anti-smooth muscle antibodies. None of the serum hepatitis B markers were positive. Symptomatic relief was obtained by prednisolone administration. Five years after the diagnosis of lupoid hepatitis, hepatocellular carcinoma (HCC) was detected by ultrasonography and computed tomography, after which hepatectomy was performed. Although transcatheter arterial embolization was done on two occasions and repeat hepatectomy was performed twice for recurrent HCC, her liver function remained good with the prednisolone treatment. Antibody for hepatitis C virus has been negative since our first check in 1992. As of this writing, the patient has been alive and well 6 years and 2 months after the first hepatectomy. There have been no previous reports of 6-year survival after hepatectomy for HCC associated with lupoid hepatitis.
Similar content being viewed by others
References
Mackay IR, Tratf LI, Cowling DC (1956) Lupoid hepatitis. Lancet I:1323–1326
Sherlock S (1985) Chronic active “lupoid” hepatitis. In: Sherlock S (ed) Diseases of the liver and biliary system. Blackwell Scientific, Oxford, pp 287–294
Kirk AP, Jain S, Pocock S, Thomas HC, Sherlock S (1980) Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis. Gut 21:78–83
Edmondson HA, Steiner PE (1954) Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies. Cancer 7:462–503
Tanabe T, Mima S, Hanew T, Mizuo H, Kanagawa H, Samejima H, Siino T, Hirata W, Fukuda M (1985) A case of lupoid hepatitis observed from acute hepatitis to hepatocellular carcinoma for 7 years (in Japanese with English abstract). Kanzo (Acta Hepatol Jpn) 26:1229–1234
Arima S, Yoshida K, Hashiguchi O, Kimura S, Ooishi S, Fujiyama S, Sagara K, Sato T (1987) A case of lupoid hepatitis associated with hepatocellular carcinoma (in Japanese with English abstract). Kanzo (Acta Hepatol Jpn) 28:772–777
Satake Y, Takada K, Ikeda K, Shiosaka T, Fujita S, Kobayashi Y (1988) A case of primary liver cell cancer complicating lupoid hepatitis. Jpn J Med 27:83–86
Motoo Y, Wakatsuki T, Tanaka N, Hinoue Y, Kobayashi K, Hattori N, Matsui O, Izumi R, Nakamura Y, Ohta G (1989) Resected case of hepatocellular carcinoma associated with lupoid hepatitis. J Gastroenterol Hepatol 4:295–298
Nishiwaki M, Nakajima T, Nagasawa M, Oohashi H, Nakamura S, Yoshizawa H, Koda A, Kino I, Kanai K (1991) A case of lupoid hepatitis accompanied with polymyositis, gastric cancer and hepatocellular carcinoma (in Japanese with English abstract). Kanzo (Acta Hepatol Jpn) 32:180–185
Ono T, Komatsu M, Nakajima K, Goto M, Kuramitsu T, Ishida H, Masamune O (1993) A case of lupoid hepatitis accompanied by hepatocellular carcinoma and pernicious anemia (in Japanese with English abstract). Kanzo (Acta Hepatol Jpn) 34:23–28
Kaneko S, Unoura M, Kobayashi K (1993) Hepatitis viruses and hepatocarcinogenesis (in Japanese with English abstract). Gan-To-Kagakuryoho (Jpn J Cancer Chemother) 20:858–863
Takahashi K, Saijo N, Kimata M (1985) Suppression of natural killer activity in patients treated with cisplatin and methylprednisolone. J Cancer Res Clin Oncol 109:78–81
Jakobovits AW, Gibson PR, Dudley EJ (1981) Primary liver cell carcinoma complicating autoimmune chronic active hapatitis. Dig Dis Sci 26:694–699
Burroughs AK, Bassendine MF, Thomas HC, Sherlock S (1981) Primary liver cell cancer in autoimmune chronic liver disease. Br Med J 282:273
Bjarnason I, Magnusson B, Bjornsson S (1982) Idiopathic chronic active hepatitis and hepatic cell carcinoma. Acta Med Scand 211:225
Lenzi M, Ballardini G, Fusconi M, Cassani F, Selleri L, Volta D, Zauli D, Bianchi FB (1990) Type 2 autoimmune hepatitis and hepatitis C virus infection. Lancet 335:258–259
Tanaka S, Kitamura T, Nakanishi K, Okuda S, Kojima J, Fujimoto I (1989) Recent advances in ultrasonographic diagnosis of hepatocellular carcinoma. Cancer 63:1313–1317
Tanaka S, Kitamura T, Nakanishi K, Okuda S, Yamazaki H, Hiyama T, Fujimoto I (1990) Effectiveness of periodic checkup by ultrasonography for the early diagnosis of hepatocellular carcinoma. Cancer 66:2210–2214
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sakaguchi, T., Nakamura, S., Suzuki, S. et al. Hepatocellular carcinoma associated with lupoid hepatitis: A review of Japanese reports. Surg Today 25, 838–842 (1995). https://doi.org/10.1007/BF00311464
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00311464