Abstract
A multivariate analysis was conducted on the survival data of 180 patients who underwent curative resection for differentiated thyroid cancer between 1966 and 1987, and the 10- and 20-year survival rates were found to be 80.6% and 73.1%, respectively. A survival analysis was also performed, testing the following factors: the patient's age at the time of diagnosis, tumor size, extraglandular extension, nodal status, distant metastases, operative procedure, sex, and histology. A univariate analysis found the initial six factors to be significant prognostic variables, but the latter two to be of no significance. On the other hand, the multivariate analysis showed that distant metastases, age, and tumor size were the most significant prognosticators. Thus, the age of the patient should be taken into consideration during the follow-up of treatment for differentiated thyroid cancer.
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References
Cady B, Sedgwick CE, Meissner WA, Bookwalter JA, Romagosa V, Weber J (1976) Changing clinical, pathologic, therapeutic and survival patterns in thyroid carcinoma. Ann Surg 184:541–543
Mazzaferri EL, Young RL (1981) Papillary thyroid carcinoma: A 10 year follow-up report of the impact of therapy in 576 patients. Am J Med 70:511–518
Tubiana M, Schlumberger M, Rougier PH, Laplanche A, Benhamou E, Gardet P, Caillou B, Travagli J-P, Parmentier C (1985) Long-term results and prognostic factors in patients with differentiated thyroid carcinoma. Cancer 55:794–804
Noguchi S, Murakami N, Kawamoto H (1994) Classification of papillary cancer of the thyroid based on prognosis. World J Surg 18:552–558
Cady B, Sedgwick CE, Meissner WA, Wool MS, Salzman FA, Weber J (1979) Risk factor analysis in differentiated thyroid cancer. Cancer 43:810–820
Frauenhoffer CM, Patchefsky AS, Cobanaglu A (1979) Thyroid carcinoma. A clinical and pathologic study of 125 cases. Cancer 43:2414–2421
Joensuu H, Klempi P, Edrola E, Tuominen J (1986) Influence of cellular DNA content on survival in differentiated thyroid cancer. Cancer 58:2462–2467
Tennvall J, Biorklund A, Moller T, Ranstam J, Akermann M (1986) Is the EORTC prognostic index of thyroid cancer valid in differentiated thyroid carcinoma? Cancer 57:1405–1414
Ito J, Noguchi S, Murakami N, Noguchi A (1980) Factors affecting the prognosis of patients with carcinoma of the thyroid. Surg Gynecol Obstet 150:539–544
Franssila K, Saxen E, Teppo L, Bjarnason O, Tulinuis H, Normann T, Ringertz N (1981) Incidence of different morphological types of thyroid cancer in the nordic countries. Acto Pathol Microbiol Scand [A] 89:49–55
Noguchi M, Mizukami Y, Michigishi T, Koyasaka N, Ohta N, Miyazaki I (1991) Multivariate study of prognostic factors in differentiated thyroid carcinomas (in Japanese with English abstract). Nippon Rinsho Geka Gakkai Zasshi (J Jpn Soc Clin Surg) 52:1413–1419
Hirabayashi RN, Lindsay S (1961) Carcinoma of the thyroid; a study of 390 patients. J Clin Endocrinol Metab 21:1596–1610
Beaugie JM, Brown CL, Doniach I, Richardson JE (1976) Primary malignant tumours of the thyroid. Br J Surg 63:173–181
Kure Y (1992) Prognostic factors of papillary carcinomas of the thyroid gland — retrospective multivariate analysis of 227 patients with median follow-up of 130 months (in Japanese with English abstract). Nippon Geka Gakkai Zasshi (J Jpn Surg Soc) 93:1420–1426
Thoresen SO, Akslen LA, Glattre E, Haldorsen T, Lund EV, Schoultz M (1989) Survival and prognostic factors in differentiated thyroid cancer — a multivariate analysis of 1,055 cases. Br J Cancer 59:231–235
Simpson WJ, McKinney SE, Carruthers JS, Gospodarowicz MK, Sutcliffe SB, Panzarella T (1987) Papillary and follicular thyroid cancer. Prognostic factors in 1,578 patients. Am J Med 83:479–488
Cady B, Rossi R, Silverman M, Wool M (1985) Further evidence of the validity of risk group definition in differentiated thyroid carcinoma. Surgery 98:1171–1178
Schelfhout LJDM, Creutzberg CL, Hamming JF, Fleuren G, Smeenk D, Hermans J, van de Velde CRJ, Goslings BM (1988) Multivariate analysis in differentiated thyroid cancer: the prognostic significance of the age factor. Eur J Cancer Clin Oncol 24:331–337
Harness JK, Thompson NW, McLeod MK, Eckhauser FE, Lloyd RV (1984) Follicular carcinoma of the thyroid gland: trend and treatment. Surgery 96:972–980
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Tsuchiya, A., Suzuki, S., Kanno, M. et al. Prognostic factors associated with differentiated thyroid cancer. Surg Today 25, 778–782 (1995). https://doi.org/10.1007/BF00311452
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DOI: https://doi.org/10.1007/BF00311452