Abstract
Portal venous flow (PVF) and portal venous pressure (PVP) were examined after the jugular or portal injection of Prostaglandin E1 (PGE) in rats partially hepatectomized by either 40% or 66%. In the 66% hepatectomized animals, the jugular injection of PGE at 5.0 μg/kg/min produced an increase in PVF concomitant with a fall in systemic arterial pressure (SAP), while PVP remained unchanged. The portal injection of PGE at 0.5 μg/kg/min increased PVF to a level equivalent to that evoked by the jugular injection of 5.0 μg/kg/min PGE, without any change in SAP. PVP was reduced synchronistically with an increase in PVF. The PVF response to a portal injection of PGE at 0.5 μg/kg/min was not reproduced in liver intact rats. These results suggest that PGE is potent in increasing PVF in the partially resected condition of the liver and that the portal vascular bed is involved in this response.
References
Geumei A, Bashour FA, Swamy BV, Nafrawi AG (1973) Prostaglandin E: its effects on hepatic circulation in dogs. Pharmacology 9:336–347
Nishida O, Moriyasu F, Nakamura T, Ban N, Tamada T, Kawasaki T, Uchino A (1990) Relationship between splenic and superior mesenteric venous circulation. Gastroenterology 98:721–725
Bhathal PS, Grossman HJ (1985) Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators. J Hepatol 1:325–337
Benacerraf B, Bilbey D, Biozzi G, Halpern BN, Stiffel C (1957) The measurement of liver blood flow in partially hepatectomized rats. J Physiol (Paris) 136:287–293
Mathie RT, Nagorney DM, Blumgart LH (1988) Liver blood flow: physiology, measurement and clinical relevance. In: Blumgart LH (ed) Surgery of the liver and biliary tract, vol 2. Churchill Livingstone, London, pp 73–87
Sakaguchi T, Arase K, Fisler JS, Bray GA (1989) Effect of a high-fat diet on firing rate of sympathetic nerves innervating brown adipose tissue in anesthetized rats. Physiol Behav 45:1177–1182
Sakaguchi T, Okamura N (1991) Gastric vagal fibers distribution and acid secretion induced by portal infusion of D-glucose. J Auton Nerv Syst 32:87–90
Ohtake M (1992) The role of the abdominal sympathetic nervous system in regulating portal venous flow and its functional distribution. Surgery Today Jpn J Surg 22:128–136
Higgins GM, Anderson RM (1931) Experimental pathology of the liver. Arch Pathol 12:186–202
Okamura T, Tsukada K, Sakaguchi T, Ohtake M, Yoshida K, Muto T (1992) Enhanced liver regeneration by FK-506 can be blocked by interleukin lα and interleukin 2. Transplant Proc 24:413–415
Nakano J, Cole B (1969) Effects of prostaglandins E and F on systemic, pulmonary, and splanchnic circulations in dogs. Am J Physiol 217:222–227
Dawson W, Jessup SJ, McDonald-Gibson W, Ramwell PW, Shaw JE (1970) Prostaglandin uptake and metabolism by the perfused rat liver. Br J Pharmacol 39:585–598
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Nakadaira, K., Tsukada, K., Sakaguchi, T. et al. A pharmacological analysis of prostaglandin E1 on portal blood flow after partial hepatectomy in rats. Surg Today 23, 277–279 (1993). https://doi.org/10.1007/BF00309242
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DOI: https://doi.org/10.1007/BF00309242