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35S incorporation into sulfated mucopolysaccharides from embryonic, normal, and neoplastic liver cells

Aufnahme von 35S in die sulfatierten Mucopolysaccharide von Embryonalen, normalen und neoplastischen Leberzellen

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Summary

The incorporation of 35S into the sulfated mucopolysaccharides from hepatoma, normal and embryonic liver cells has been studied by means of anion exchange chromatography of the isolated mucopolysaccharide. Comparatively to liver cells, while showing a higher labeling of low sulfated mucopolysaccharides the hepatoma cells incorporate much less 35S into the heparin fraction.

Zusammenfassung

Die Aufnahme von 35S in die sulfatierten Mucopolysaccharide von Lebertumor, normalen und embryonalen Leberzellen wurde durch Anionenaustauschchromatographie der isolierten Mucopolysaccharide erforscht. Im Vergleich zu Leberzellen nehmen die Lebertumorzellen viel weniger 35S in die Heparin-Fraktion auf, während sie eine höhere Markierung von niedrig sulfatierten Mucopolysacchariden zeigen.

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Authors and Affiliations

  1. Innere Klinik und Poliklinik (Tumorforschung), Universitätsklinikum der GHS Essen, Federal Republic of Germany

    L. J. Anghileri

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  1. L. J. Anghileri
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This work has been supported by a grant from the Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen.

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Anghileri, L.J. 35S incorporation into sulfated mucopolysaccharides from embryonic, normal, and neoplastic liver cells. Z. Krebsforsch. 85, 73–77 (1976). https://doi.org/10.1007/BF00308131

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  • DOI: https://doi.org/10.1007/BF00308131

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