Abstract
The authors present specific clinical features of brain tumors occurring in immature brain in comparison with those of older infants and children. Twenty-six neonatal brain tumors, which accounted for 11.3% of 231 brain tumors diagnosed in the 1st year of life collected in a cooperative study in Japan, were analyzed. Although astrocytomas were invariably common tumors in each age group, comprising 25.0% for all pediatric brain tumors, teratomas were the most common type of neonatal brain tumors and accounted for 33.4% in this age group. Location of tumors in the immature brain was more striking, involving the posterior fossa region less commonly, as in 11.1% in neonatal, 29.5% in infantile, and 41.4% in all pediatric age groups. Surgical intervention was performed in 97.4% of the infantile and 79.1% of the neonatal cases, but total or subtotal resection of the mass was achieved only in 58.9% in the infants and 73.7% in the neonates. There was more strict limitation in performing the adjuvant therapies in the immature age groups. Radiation therapy and chemotherapy were given only in 32.0% and 27.6%, respectively, in the neonatal cases. The prognosis was extremely poor in the immature cases: 1-year, 5-year, and 10-year survivial rates were 59.3%, 26.1%, 11.5% in the infants, and 43.5%, 23.8%, 7.1% in the neonates, respectively. Of the neonates, 76% and of the infants 73.1% were retarded. The present study delineates the characteristic clinical features of tumors involving immature brain and emphasized that establishment of more specific therapeutic modalities is urgent.
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Arnstein LH, Boldrey Z, Naffziger HC (1950) A case report and survey of brain tumors during the neonatal period. J Neurosurg 8:315–319
Azar-Kia B, Krishman UR, Schechter MM (1975) Neonatal craniopharyngioma. J Neurosurg 42:91–93
Ellams ID, Neuhäuser G, Agnoli AL (1986) Congenital intracranial neoplasms. Child's Nerv Syst 2:165–168
Fessard C (1968) Congenital tumors in infancy: 66 clinicoanatomical case studies. Am J Dis Child 115:302–308
Fraumeni JF, Miller RW (1969) Cancer deaths in the newborn. Am J Dis Child 117:186–189
Gass HH (1956) Large calcified craniopharyngioma and bilateral subdural hematoma present at birth. J Neurosurg 13:514–519
Isaacs H (1985) Perinatal (congenital and neonatal) neoplasms: a report of 110 cases. Pediatr Pathol 3:165–216
Itoh Y, Kowada M, Mineura K, Kojima H (1987) Congenital glioblastoma of the cerebellum with cytofluorometric deoxyribonucleic acid analysis. Surg Neurol 27:163–167
Jooma R, Kendall BE, Hayward RD (1984) Intracranial tumors in neonates: a report of seventeen cases. Surg Neurol 21:165–170
Koos WT, Millar MH (1971) Intracranial tumors of infants and children. Mosby, St Louis, Mo
Lapras C, Guilburd JN, Guyotal J, Patet JD (1988) Brain tumors in infants: a study of 76 patients operated upon. Child's Nerv Syst 4:100–103
Nomura K (1988) The epidemiology and statistics of brain tumors in Japan (in Japanese). No To Shinkei 40:797–806
Oi S, Yamada U, Urui S, Matsumoto S (1988) Familial occurrence of congenital anomalies of the central nervous system. Neurol Med Chir (Tokyo) 28:562–567
Oi S, Matsumoto S, Choi JU, Kang JK, Wong T, Wang C, Chan TST (1990) Brain tumors diagnosed in the first year of life in five Far-Eastern countries. Statistical analysis of 307 cases. Child's Nerv Syst (1990) 6:79–85
Oi S, Tamaki N, Kondo T, Nakamura H, Kudo H, Suzuki H, Sasaki M, Matsumoto S, Ueda Y, Katayama K, Mochizuki M (1990) Massive congenital intracranial teratoma diagnosed in utero. Child's Nerv Syst (in press)
Raimondi AJ, Tomita T (1983) Brain tumors during the first year of life. Child's Brain 10:193–207
Sabet LM (1982) Congenital glioblastoma multiforme associated with congestive heart failure. Arch Pathol Lab Med 106:31–34
Sakamoto K, Kobayashi N, Otsubo N, Tanaka Y (1986) Intracranial tumors in the first year of life. Child's Nerv Syst 2:126–129
Sano K (1987) A statistical study of brain tumors in Japan: general features. Jpn J Clin Oncol 17:19–28
Sato O, Tamura A, Sano K (1975) Brain tumors of early infants. Child's Brain 1:121–125
Solitare GB, Krigman MR (1964) Congenital intracranial neoplasm. A case report and review of the literature. J Neuropathol Exp Neurol 23:280–292
Tabaddor K, Shulman K, Dal Canto MC (1974) Neonatal craniopharyngioma. Am J Dis Child 128:381–383
Takaku A, Kodama N, Ohara H, Hori S (1978) Brain tumor in newborn babies. Child's Brain 4:365–375
Tamura H, Kury G, Suzuki K (1966) Intracranial teratomas in fetal life and infancy. Obstet Gynecol 27:134–141
Tomita T, McLone DG (1985) Brain tumors during the first twenty-four months of life. Neurosurgery 17:913–919
Wakai S, Arai T, Nagai M (1984) Congenital brain tumors. Surg Neurol 21:597–609
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Oi, S., Kokunai, T. & Matsumoto, S. Congenital brain tumors in Japan (ISPN Cooperative Study): specific clinical features in neonates. Child's Nerv Syst 6, 86–91 (1990). https://doi.org/10.1007/BF00307927
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DOI: https://doi.org/10.1007/BF00307927