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Rheumatology International

, Volume 13, Issue 2, pp 61–64 | Cite as

Pentosan polysulphate and glycosaminoglycan polysulphate stimulate the synthesis of hyaluronan in vivo

  • D. J. Francis
  • N. Hutadilok
  • P. Kongtawelert
  • P. Ghosh
Originals

Summary

Pentosan polysulphate (PPS) and glycosaminoglycan polysulphate (GAGPS) were examined for their ability to alter hyaluronan synthesis in vivo. The inflamed rat subcutaneous ari pousch model was used for the study. PPS or GAGPS injected into the air pouch at a dose of 2.5 mg/kg daily for 7 days resulted in higher molecular weight hyaluronan in the pouch fluid compared with control non-drug-treated pouch fluid. The quantity of the hyaluronan was increased by PPS, but not by GAGPS. We concluded that both drugs could be beneficial in the treatment of inflammatory arthritides in which a decrease in normal synovial hyaluronan concentration and molecular weight occurs.

Key words

Pentosan polysulphate Glycosaminoglycan polysulphate Hyaluronan Air pouch model 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • D. J. Francis
    • 1
    • 2
  • N. Hutadilok
    • 1
  • P. Kongtawelert
    • 1
  • P. Ghosh
    • 1
  1. 1.Raymond Purves Research LaboratoriesThe University of Sydney, The Royal North Shore HospitalSt. LeonardsAustralia
  2. 2.Department of RheumatologyThe Royal North Shore HospitalSt. LeonardsAustralia

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