Rheumatology International

, Volume 13, Issue 2, pp 45–51 | Cite as

Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis

  • U. Sack
  • R. W. Kinne
  • T. Marx
  • P. Heppt
  • S. Bender
  • F. Emmrich


Interleukin-6 (IL-6) was detected at low levels in plasma [0.014±0.006 ng/ml (mean ± SEM] and in high amounts in synovial fluid [SF; 2.6±2.2 ng/ml (mean ± SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n=15) or with histological parameters of acute local synovitis (n=10) was observed. In contrast, SF IL-6 was positively correlated with histological characteristics of chronic synovitis (n=10; P≤0.01) and elevated plasma IgG concentrations (n=15; P≤0.05). In vitro concentrations of IL-6 comparable to those detected in SF increased the production of both IgG and IgM by synovial membrane mononuclear cells. The present results contribute to the view that high local IL-6 concentrations in SF promote chronic synovitis in RA.

Key words

Interleukin-6 Synovial fluid Chronic rheumatoid arthritis Histology 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • U. Sack
    • 1
  • R. W. Kinne
    • 1
  • T. Marx
    • 1
  • P. Heppt
    • 2
  • S. Bender
    • 3
  • F. Emmrich
    • 1
  1. 1.Max-Planck-Society, Clinical Research Unit for Rheumatology/Immunology, Institute of Clinical Immunology and Rheumatology, Department of Medicine IIIUniversity of Erlangen-NurembergGermany
  2. 2.Department of OrthopedicsUniversity of Erlangen-NurembergGermany
  3. 3.Institute of BiochemistryAachenGermany

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