Summary
The treatment by 6 hydroxydopamine produces cytological modifications at the level of the aminergic fibres belonging to the hypophysial innervation in Gasterosteus aculeatus. Dark dense bodies, which contain altered mitochondria and granules, appear in several nerve endings. These structures visualize the action of 6 hydroxydopamine inducing a degeneration of the aminergic nerve endings. Some results have been obtained concerning the distribution of the degenerating nerve fibres in the different zones of the neurohypophysis. In the rostral zone few fibres are degenerating—in the middle zone a greater number of them has been found—but the fibres running between the cells of the pars intermedia show the weakest effect. They are only depleted, but they dont contain dark bodies.
The administration of 6 hydroxydopamine produces a strong darkening of the skin melanophores. This effect may be due to a direct action on the innervation of the melanophores or to a modification of the aminergic control system about the hypophysial M.S.H. cells.
Résumé
Le traitement par la 6 hydroxydopamine modifie l'aspect cytologique des fibres aminergiques faisant partie de l'innervation hypophysaire de Gasterosteus aculeatus. Dans plusieurs terminaisons on voit apparaître des corps denses hétéromorphes dans lesquels on reconnait des mitochondries et des granules. Ces images cytologiques de dégénérescence traduisent l'action de la 6 hydroxydopamine au niveau des terminaisons aminergiques. Ces altérations ont été décelées avec une fréquence différente dans les trois zones de la neurohypophyse. Dans la zone antérieure elles sont peu abondantes; elles se trouvent en plus grand nombre dans la zone médiane. Les fibres aminergiques qui se terminent entre les cellules de la métaadénohypophyse sont peu modifiées. Elles paraissent vidées, mais on n'y décèle aucun corps dense.
L'administration de 6 hydroxydopamine provoque un noircissement très prononcé des mélanophores dermiques. Cet effet pourrait résulter, soit d'une action directe sur l'innervation aminergique des mélanophores, soit d'une modification du système de contrôle des cellules à M.S.H. du lobe intermédiaire de l'hypophyse.
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Follénius, E. Cytologie fine de la dégénérescence des fibres aminergiques intrahypophysaires chez le poisson téléostéen Gasterosteus aculeatus après traitement par la 6 hydroxydopamine. Z.Zellforsch 128, 69–82 (1972). https://doi.org/10.1007/BF00306889
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DOI: https://doi.org/10.1007/BF00306889