Summary
Multiple intraperitoneal injections of AIA in rats cause a decrease in matrix material and loss of endogenous peroxidatic activity in hepatic cell microbodies. These changes are detectable as early as 48 hours after commencing injections and are prominent by 5 days. On cessation of injections, recovery of normal microbody morphology is rapid but peroxidatic activity of microbodies returns more slowly. There is no evidence of increased destruction of microbodies during the recovery period. These observations support the concept that microbody constituents may be able to exchange independently of turnover of the entire organelle.
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This study was supported in part by research grant HD-1337 to R.L.W. from the Institute of Child Health and Human Development, United States Public Health Service. The work was initiated while the authors were affiliated with the Department of Anatomy at the University of Minnesota. Dr. Wood was a member of the regular staff and Dr. Legg was on leave from Monash University. The authors thank Dr. Douglas E. Kelly for critical review of the manuscript.
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Legg, P.G., Wood, R.L. Effects of allylisopropylacetamide (AIA) on the fine structure and peroxidase activity of microbodies in rat hepatic cells. Z.Zellforsch 128, 19–30 (1972). https://doi.org/10.1007/BF00306885
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DOI: https://doi.org/10.1007/BF00306885