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Die Wirkung von Methyl- und Äthylnitrosourethan, Diäthylsulfat und Methylmethansulfonat auf zwei Genorte von Neurospora sowie einen Mutationsort von Saccharomyces

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Summary

Reverse mutation experiments were performed with the site ad6-45 in Saccharomyces cerevisiae and two gene loci of Neurospora crassa ad (38701) and inos (37401). The mutant in yeast could be reverted with nitroso-methyl- (NMU) and nitroso-ethylurethane (NEU) but was refractory to methyl methanesulfonate (MMS) and diethylsulfate (DES). In Neurospora NMU reverted both requirements, DES only the adenine requirement, NEU reverted neither one. Thus the mutagenic specificity of an agent depends on the structure of the entire molecule, transport-form, rather than on its ability to methylate or ethylate.

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Authors and Affiliations

  1. Forstbotanisches Institut der Universität 78, Bertoldstr. 17, Freiburg i. Br.

    H. Marquardt, R. Schwaier & F. K. Zimmermann

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  1. H. Marquardt
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  2. R. Schwaier
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  3. F. K. Zimmermann
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Marquardt, H., Schwaier, R. & Zimmermann, F.K. Die Wirkung von Methyl- und Äthylnitrosourethan, Diäthylsulfat und Methylmethansulfonat auf zwei Genorte von Neurospora sowie einen Mutationsort von Saccharomyces . Molec. Gen. Genetics 99, 1–4 (1967). https://doi.org/10.1007/BF00306452

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  • DOI: https://doi.org/10.1007/BF00306452

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