Abstract
Intraparenchymal hemorrhage in the left frontal lobe suddenly occurred in a 7-year-old girl who had undergone partial removal of an undifferentiated brain stem glioma and received craniospinal (30 Gy) and posterior fossa booster (20 Gy) irradiation at the age of 20 months. The brain hemorrhage was thought to be delayed irradiation effect. Follow-up neuro-imaging at age 9 years showed two more small occult chronic and subacute hemorrhages in the brain. The possibility of repeated hemorrhage as a delayed reaction to brain irradiation is emphasized.
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Allen JC, Miller DC, Budzilovich GN, Epstein FE (1991) Brain and spinal cord hemorrhage in long-term survivors of malignant pediatric brain tumors: a possible late effect of therapy. Neurology 41:148–150
Duffner PK, Cohen ME, Thomas PRM, Lansky SB (1985) The long-term effects of cranial irradiation on the central nervous system. Cancer 56:1841–1846
Fike JR, Cann CE, Phillips TL, Bernstein M, Gutin FH, Turowski K, Weaver KA, Davis RL, Higgins RJ, DaSilva V (1985) Radiation brain damage induced by interstitial 125I sources: a canine model evaluated by quantitative computed tomography. Neurosurgery 16:530–537
Hughes EN, Shillito J, Sallan SE, Loeffler JS, Cassady JR, Tarbell NJ (1988) Medulloblastoma at the joint center for radiation therapy between 1968 and 1984. Cancer 61:1992–1998
Lampert PW, Davis RL (1964) Delayed effects of radiation on the human central nervous system. “Early” and “late” delayed reactions. Neurology 14:912–917
Leibel SA, Sheline GE (1987) Radiation therapy for neoplasms of the brain. J Neurosurg 66:1–22
Rubinstein LJ (1972) Tumors of the central nervous system. In: Firminger HI (ed) Atlas of tumor pathology, 2nd series, fascicle 6. Armed Forces Institute of Pathology, Washington, DC, pp 349–360
Tamura M, Miyazaki M, Kunimine H, Nakamura M, Ohye C (1989) Undifferentiated gliomas of the brain stem. Child's Nerv Syst 5:32–34
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Tamura, M., Ono, N., Zama, A. et al. Delayed brain hemorrhage associated with prophylactic whole brain irradiation for pediatric malignant brain tumor: a case report. Child's Nerv Syst 9, 300–301 (1993). https://doi.org/10.1007/BF00306280
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DOI: https://doi.org/10.1007/BF00306280