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Experimentally induced cortical malformations in rats

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Abstract

Different cortical malformations were produced in rats by a single dose of X-rays (200 cGy) given on different days during gestation. These include large cortical ectopic masses after irradiation on day 14; segmentation of the cerebral cortex following irradiation on days 15, 17, 19; and a four-layered “lissencephalic” cortex following irradiation on day 16. Other types of cortical malformation were produced in rats aged 0–2 days by one of the following procedures: focal cortical freezing, focal electrocoagulation, cortical aspiration, and focal brushing of the meninges with a blunt needle covered with cotton. These latter abnormalities include laminar necrosis of layer V, focal cortical dysplasia reminiscent of microgyria, status verrucosus deformis and porencephaly. Experimentally induced cortical malformations in rats can help to increase our understanding of normal and abnormal neurogenesis and organisation of the human cerebral cortex.

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References

  1. Altman J, Bayer SA (1990) Vertical compartmentation and cellular transformation in the germinal matrices of the embryonic rat cerebral cortex. Exp Neurol 107:23–35

    Google Scholar 

  2. Barth P (1987) Disorders of neuronal migration. Can J Neurol Sci 14:1–6

    Google Scholar 

  3. Berry M, Rogers AW (1965) The migration of neuroblasts in the developing cerebralcortex. J Anat (Lond) 99:691–709

    Google Scholar 

  4. Caviness VS, Williams RS (1984) Cellular patterns in developmental malformations of neocortex: neuron-glial interactions. In: Suzuki Y, Yabuuchi H (eds) The developing brain and its disorders. University of Tokyo Press, Tokyo, pp 43–67

    Google Scholar 

  5. Celio MR (1990) Calbindin D-28k and parvalbumin in the rat nervous system. Neuroscience 35:475

    Google Scholar 

  6. D'Agostino AN, Brizee KR (1966) Radiation necrosis and repair in rat fetal cerebral hemisphere. Arch Neurol 15:615–628

    Google Scholar 

  7. Dvorák K, Feit J, Juránkova Z (1978) Experimentally induced focal microgyria and status verrucosus deformis in rats. Pathogenesis and interrelation. Histological and autoradiographical study. Acta Neuropathol 44:121–129

    Google Scholar 

  8. Ferrer I, Catalá I (1991) Unlayered polymicrogyria: structural and developmental aspects. Anat Embryol 184:517–528

    Google Scholar 

  9. Ferrer I, Fernández-Alvarez E (1977) Lisencefalia: agiria. J Neurol Sci 34:109–120

    Google Scholar 

  10. Ferrer I, Xumetra A, Santamaria J (1984) Cerebral malformation induced by prenatal X-irradiation: an autoradiographic and Golgi study. J Anat (Lond) 138:81–93

    Google Scholar 

  11. Friede RL (1989) Developmental neuropathology. Springer, Berlin Heidelberg New York, pp 309–346

    Google Scholar 

  12. Hicks SP, D'Amato CJ (1968) Cell migration to the isocortex in the rat. Anat Rec 160:619–634

    Google Scholar 

  13. Hicks SP, D'Amato CJ, Lowe MJ (1959) The development of the mammalian nervous system. J Comp Neurol 113:435–469

    Google Scholar 

  14. Humphreys P, Rosen GD, Press DM, Sherman GF, Galaburda AM (1991) Freezing lesions of the developing rat brain: a model of cerebrocortical microgyria. J Neuropathol Exp Neurol 50:145–160

    Google Scholar 

  15. Jellinger K, Rett A (1976) Agyria-pachygyria (lissencephaly syndrome). Neuropädiatrie 7:66–91

    Google Scholar 

  16. Miller MW (1988) Development of projection and local circuit neurons in neocortex. In: Peters A, Jones EG (eds) Development and maturation of the cerebral cortex. (Cerebral cortex, vol 7). Plenum Press, New York, pp 133–175

    Google Scholar 

  17. Raedler E, Raedler A (1978) Autoradiographic study of early neurogenesis in rat neocortex. Anat Embryol 154:267–284

    Google Scholar 

  18. Rakic P (1988) Specification of cerebral cortical areas. Science 241:170–176

    Google Scholar 

  19. Schmahl W, Weber L, Kriegel H (1979) X-irradiation of mice in the early fetal period. I. Assessment of lasting CNS deficits developing mainly in the subsequent perinatal period. Z Radiat Onkol 155:347–357

    Google Scholar 

  20. Suzuki M, Choi BH (1991) Repair and reconstruction of the cortical plate following closed cryogenic injury to the neonatal rat cerebrum. Acta Neuropathol 82:93–101

    Google Scholar 

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  1. Unidad Neuropatología, Servicio Anatomía Patológica, Hospital Príncipes de España, Universidad de Barcelona, E-08907, Hospitalet de Llobregat, Spain

    I. Ferrer

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  1. I. Ferrer
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Ferrer, I. Experimentally induced cortical malformations in rats. Child's Nerv Syst 9, 403–407 (1993). https://doi.org/10.1007/BF00306193

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  • DOI: https://doi.org/10.1007/BF00306193

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