Skip to main content
Log in

The possible role of the carcinoembryonic antigen (CEA) and other carcinofetal antigens in malignant and benign diseases of the gastrointestinal tract

  • Guest Editorial
  • Published:
Zeitschrift für Krebsforschung und Klinische Onkologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Abelev,G.I., Perova,S.D., Kramkova,N.J., Postnikova,Z.A., Irlin,I.S.: Production of embryonal serum globulin by the transplantable mouse hepatomas. Transplantation 1, 174 (1963)

    Google Scholar 

  • Abelev,G.I.: Antigenic structure of chemically induced hepatomas. Progr. Exp. Tumor Res. (Basel) 7, 104 (1965)

    Google Scholar 

  • Abelev,G.I., Assercritova,I.V., Kraevsky,N.A., Perova,S.D., Perevodclirkova,N.D.: Embryonal serum alpha globulin in cancer patients: diagnostic value. Int. J. Cancer 2, 551 (1967)

    Google Scholar 

  • Akai,S., Kato,K.: Serum AFP-positive stomach cancer. Gann Monogr. on Cancer Res. 14, 148 (1973)

    Google Scholar 

  • Aussel,C., Uriel,J., Mercier-Bodard,C.: Rat alpha foetoprotein: isolation, characterization and oestrogen binding properties. Biochimie 55, 1431 (1973)

    Google Scholar 

  • Banjo,C., Gold,P., Gehrke,C.W., Freedman,S.O., Krupey,J.: Preparation and isolation of immunologically active glycopeptides from carcinoembryonic antigen (CEA). Int. J. Cancer, 13, 151 (1974)

    Google Scholar 

  • Booth,S.N., Jamieson,G.C, King,J.P., Leonard,J., Oates,G.D., Dykes,P.W.: Carcinoembryonic antigen in management of colorectal carcinoma. Br. Med. J. 4, 183 (1974)

    Google Scholar 

  • Booth,S.N., King,F.P., Leonard,J.C., Dykes,P.W.: The significance of elevation of serum carcinoembryonic antigen (CEA) levels in inflammatory diseases of the intestine. Scand J. Gastroenterol. 9 (7), 651 (1974)

    Google Scholar 

  • Buffe,D., Rimbaut,C., Burtin,P.: Présence d'une protéine d'origine tissulaire l' 2H globuline dans le sérum des efants porteurs de tumeur. Int. J. Cancer 5, 85 (1968)

    Google Scholar 

  • Buffe,D., Rimbaut,C., Lemerle,J., Schweissguth,O., Burtin,P.: Présence d'une ferroprotéine d'origine tissulaire, l' 2H globuline dans le séum des enfants porteurs de tumeur. Int. J. Cancer 5, 85 (1970)

    Google Scholar 

  • Burtin,P., Martin,E., Sabine,M.C., von Kleist,S.: Immunological study of polyps of the colon. J. Nat. Cancer Inst. 48, 25 (1972)

    Google Scholar 

  • Burtin,P., Sabine,M.C., Chavanel,G.: Presence of carcinoembryonic antigen in children's colonic mucosa. Int. J. Cancer 10, 72 (1972)

    Google Scholar 

  • Burtin,P., Chavanel,G., Hirsch-Marie,H.: Characterization of a second normal antigen that cross reacts with CEA. J. of Immunol. 111, 1926 (1973)

    Google Scholar 

  • Coligan,J.E., Henkart,P.A., Todd,C.W., Terry,W.D.: Heterogenecity of the carcinoembryonic antigen. Immunochemistry 10, 59 (1973)

    Google Scholar 

  • Collatz,E., von Kleist,S.: Burtin,P.: Further investigations of circulating antibodies in colon cancer patients on the autoantigenicity of the carcino-embryonic antigen. Int. J. Cancer 8, 298 (1971)

    Google Scholar 

  • Crichlow,R.W., White,R.R.: Search for carcinoembryonic antigen in adenomas of the colon. Proc. Amer. Ass. Cancer Res. 11, 18 (1970)

    Google Scholar 

  • Darcy,D.A., Turberville,C., James,R.: Immunological study of carcinoembryonic antigen (CEA) and a related glycoprotein. Br. J. Cancer 28, 147 (1973)

    Google Scholar 

  • Denk,H., Tappeiner,G., Eckestorfer,R., Holzner,J.H.: Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor-cell differentiation. Int. J. Cancer 10, 262 (1972)

    Google Scholar 

  • Dhar,P., Moore,T., Zamcheck,N., Kupchik,H.Z.: Carcinoembryonic antigen (CEA) in colonic cancer, use in preoperative and postoperative diagnosis and prognosis. J. Amer. Med. Ass. 221, 31 (1971)

    Google Scholar 

  • Doos,W.G., Wolff,W.I., Shinya,H., Dechabon,A., Stenger,R.J., Gottlieb,L.S., Zamcheck,N.: CEA levels in patients with colorectal polyps. Cancer 36, 1996 (1975)

    Google Scholar 

  • Edgington,T.S., Astarita,R.W., Plow,E.T.: Association of an isomeric species of carcinoembryonic antigen (CEA-S) with neoplasia of the gastrointestinal tract. New Engl. J. Med. 293, 103–107 (1975)

    Google Scholar 

  • Fritsché,R., Mach,J.P.: Identification of a new oncofoetal antigen associated with several types of human carcinomas. Nature 258, 734 (1975)

    Google Scholar 

  • Gitlin,D., Perricelli,A., Gitlin,G.: Synthesis of alpha fetoprotein by liver, yolksac, and gastrointestinal tract of the human conceptus. Cancer Res. 32, 979 (1972)

    Google Scholar 

  • Gold,P., Freedman,S.: Demonstration of tumor specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med. 121, 439 (1965)

    Google Scholar 

  • Gold,Ph., Freedman,S. Specific carcinoembryonic antigens of the human digestive system. J. Exp. Med. 122, 467 (1965)

    Google Scholar 

  • Gold,Ph., Krupey,J., Ansari,H.: Position of the carcinoembryonic antigen of the human digestive system in ultrastructure of the thumor cell surface. J. Nat. Cancer Inst. 45, 219 (1970)

    Google Scholar 

  • Gold,J.M., Freedman,S.O., Gold,P.H.: Human anti-CEA antibodies detected by radioimmunoelectrophoresis. Nature New Biol. 239, 60 (1972)

    Google Scholar 

  • Häkkinen,J.P.: Differentiation of antigenic gastric cancer sulphopolysaccarides from the metaplastic “intestinal” type sulphopolysaccarides. Scand. J. Gastroent. 2, 39 (1967)

    Google Scholar 

  • Hansen,H.J, Snyder,J.J., Miller,E., Vandevoorde,J.V., Miller,O.N., Hines,L.R., Burns,J.J.: CEA assay. A laboratory adjunct in the diagnosis and management of cancer. Human Pathol. 5, 139 (1974)

    Google Scholar 

  • Herberman,R.B., Hollinshead,A.C., von Kleist,S.: Relationship of skin reactive intestinal cancer antigen to the carcinoembryonic antigen of Gold and other antigens. Ann. Immunol. (Inst Pasteur) 124 c, 25 (1973)

    Google Scholar 

  • Hirai,H., Nishi,S., Watabe,H., Tsukaka,Y.: Some chemical, experimental, and clinical investigations of fetoprotein. Gann. Monogr. Cancer Res. 14, 19 (1973)

    Google Scholar 

  • Hirszfeld,L., Halber,U., Rosenblatt,J.: Untersuchungen über Verwandtschaftsreaktionen zwischen Embryonal und Krebsgewebe. II. Menschenembryo und Menschenkrebs. Z. Immunitätsforsch. 75, 209 (1932)

    Google Scholar 

  • Holburn,A.M., Mach,J.P., Mc Donald,D., Newlands,M.: Studies of the association of the A, B, and Lewis blood group antigens with carcinoembryonic antigen (CEA). Immunology 26, 831 (1974)

    Google Scholar 

  • Hollinshead,A.C, McWright,C.G., Alford,T.C, Glew,D.H., Gold,P.H., Herberman,R.B.: Separation of skin reactive intestinal cancer antigen from the carcinoembryonic antigen of Gold. Science 177, 887 (1972)

    Google Scholar 

  • Holyoke,D., Reynoso,G., Chu,T.M.: Carcinoembryonic antigen (CEA) in patiens with carcinoma of the digestive tract. Ann. Surg. 176, 559 (1972)

    Google Scholar 

  • Holyoke,E.D., Chu,T.M., Murphy,G.P.: CEA as a monitor of gastrointestinal malignancy. Cancer 35, 830 (1975)

    Google Scholar 

  • von Kleist,S., Burtin,P.: Mise en évidence dans les tumeurs coliques humaines d'antigénes non présents dans la muqueuse colique de l'adulte normal. C.R. Acad. Sc. Paris 263, 1543 (1966)

    Google Scholar 

  • von Kleist,S., Burtin,P.: Localisation cellulaire d'un antigène embryonnaire de tumeurs coliques humaines. Int. J. Cancer 4, 874(1969)

    Google Scholar 

  • von Kleist,S., Burtin,P.: Isolation of a foetal antigen from human colonic tumors. Cancer Res. 29, 1961 (1969)

    Google Scholar 

  • von Kleist,S.: Etude d'un antigéne spécificique de tumeurs coliques humaines. Biol. Méd. 60, 237 (1971)

    Google Scholar 

  • von Kleist,S., Chavanel,G., Burtin,P.: Identification of a normal antigen that cross reacts with the carcinoembryonic antigen. Proc. Natl. Acad. Sci. (USA) 69, 2492 (1972)

    Google Scholar 

  • Krupey,J., Wilson,T., Freedman,S.O., Gold,P.: The preparation of purified carcinoembryonic antigen of the human digestive system from large quantities of tumor tissue. Immunochemistry 9, 617 (1972)

    Google Scholar 

  • Lafon,J., Bonet,C., Masseyeff,R., Delmont,J.: Radioimmunoassay of α-foetoprotein in metastatic liver cancer. Digestion (Basel) 8, Nos. 5 and 6 (1973)

    Google Scholar 

  • Lamerz,R., Fateh-Moghadam,A.: Carcinofetal antigens. I. α-fetoprotein. Klin. Wochenschr. 53, 147 (1975)

    Google Scholar 

  • Lamerz,R., Fateh-Moghadam,A.: Carcinofetal antigens. II. Carcinoembryonic antigen (CEA). Klin. Wochenschr. 53, 193 (1975)

    Google Scholar 

  • Lehmann,F.G.: Epidemiology and diagnosis of primary liver carcinoma. Internist (Berlin) 14, 274 (1973)

    Google Scholar 

  • Lo Gerfo,P., Krupey,J., Hansen,H.J.: Demonstration of an antigen common to several varieties of neoplasia. New Engl. J. Med. 285, 138 (1971)

    Google Scholar 

  • Lo Gerfo. P., Herter,F.P., Bennett,S.J.: Absence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies. Int. J. Cancer 9, 344 (1972)

    Google Scholar 

  • Mach,J.P., Pusztaszeri,G.: Carcinoembryonic antigen (CEA): demonstration of a partial identity between CEA and a normal glycoprotein. Immunochemistry 9, 1031 (1972)

    Google Scholar 

  • Mach,J.P., Pusztaszeri,G., Mac Donald,D., Bertholet,M.M.: Carcinoembryonic antigen (CEA). Use and limitations of the CEA radioimmunoassay in the diagnosis and follow-up of colorectal carcinoma. Johns Hopkins Med. J. Suppl. 3, 369 (1974)

    Google Scholar 

  • Martin,F., Martin,M.S.: Demonstration of antigens related to colonic cancer in the human digestive system. Int. J. Cancer 6, 352 (1970)

    Google Scholar 

  • Reynoso,G., Chu,T.M., Holyoke,D., Cohen,E., Nemoto,T., Wang,J.J., Chuang,J., Guinan,P., Murphy,G.P.: Carcinoembryonic antigen in patiens with different cancers. Jama 220, 361 (1972)

    Google Scholar 

  • Reynoso,G., Chu,T.M., Holyoke,D., Murphy,G.P.: Carcinoembryonic antigen in patients with different cancers. Clin. Res. 19, 672 (1971)

    Google Scholar 

  • Roche Study: A monograph. Basel: Hoffmann-La Roche

  • Rosai,J., Tillack,T.W., Marchesi,V.T.: Membrane antigens of human colonic carcinoma and non tumoral colonic mucosa: results obtained with a new isolation method. Int. J. Cancer 10, 357 (1972)

    Google Scholar 

  • Ruoslahti,E., Seppälä,M.: α-foetoprotein in normal serum. Nature (Lond.) New Biol. 235, 161 (1972)

    Google Scholar 

  • Ruouslahti,E., Seppälä,M., Vuopio,P., Saksela,E., Pelto-Kallio,P.: Radioimmunoassay of α-foetoprotein in primary and secondary cancer of the liver. J. Natl. Cancer. Inst. 49, 623(1972)

    Google Scholar 

  • Ørjasaeter,H.: Demonstration of carcinoembryonic antigens (CEA), nonspecific crossreacting antigen (NCA) and an associated α-protein in normal human tissues and fluids by the immunodiffusion technique. Acta Path. Microbiol. Scand. B 82, 387–395 (1974)

    Google Scholar 

  • Tatarinov,Y.S.: Content of embryospecific alpha globulin in fetal and neonatal sera and sera from adult humans with primary carcinoma of the liver. Fed. Proc. (Trans. Suppl.) 25, 344 (1966)

    Google Scholar 

  • Terry,W.D., Henkart,P.A., Coligan,J.F., Todd,C.W.: Structural studies of the major glycoprotein in preparations with carcinoembryonic antigen activity. J. Exp. Med. 136, 200 (1972)

    Google Scholar 

  • Todd,C.W., Egan,M.L., Lautenschleger,J.T., Coligan,J.E.: Dosage, isolement et caracterisation de l'antigène carcinoembryonnaire. Ann. Inst. Pasteur 122, 841 (1972)

    Google Scholar 

  • Thomson,D.M., Krupey,J., Freedman,S.O., Gold,P.: The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. P.N.A.S. (USA) 64, 161 (1969)

    Google Scholar 

  • Tomita,J.T., Safford,J.W., Hirata,A.A.: Antibody response to different determinants on carcinoembryonic antigen (CEA). Immunology 26, 291 (1974)

    Google Scholar 

  • Uriel,J., de Nechand,B.: La recherche d'alphafoetoproteine en pathologie humaine. Etat actuel de la question. Ann. Inst. Pasteur 122, 829 (1972)

    Google Scholar 

  • Wada,T., Anzai,T., Yachi,A., Takahashi,A., Sakamoto,S.: Incidences of three different foetal proteines in sera of patients with primary hepatoma. In: Peeters, H. (Ed.): Protides of biol. fluids, Vol. 18, pp. 221 Oxford: Pergamon Press 1971

    Google Scholar 

  • Witebsky,E.: Disponibilität und Spezifität alkohollöslicher Strukturen von Organen und bösartigen Geschwülsten. Z. Immunotätsforsch. 62, 59 (1929)

    Google Scholar 

  • Zamcheck,N., Moore,T.L., Dhar,P., Kupchik,H.: Immunologic diagnosis and prognosis of human digestive tract cancer carcinoembryonic antigens. N. Engl. J. Med. 286, 83 (1972)

    Google Scholar 

  • Zamchek,N., Moore,T.L.: Ulcerative colitis-colon cancer immunologically linked disorders. N. Engl. J. Med. 287, 436 (1972)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

von Kleist, S. The possible role of the carcinoembryonic antigen (CEA) and other carcinofetal antigens in malignant and benign diseases of the gastrointestinal tract. Z. Krebsforsch. 90, 1–11 (1977). https://doi.org/10.1007/BF00306017

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00306017

Navigation