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Experiments on the carcinogenic effect of ortho-toluol-sulfonamid (OTS)

Zeitschrift für Krebsforschung und Klinische Onkologie volume 91, pages 19–22 (1978)Cite this article

Summary

Ortho-toluol-sulfonamid was applied to male and female Sprague-Dawley rats in daily doses of 200 mg/kg and 20 mg/kg bodyweight respectively. The maximum dose applied amounted to 17 g/kg. A shortening of the average life expectation was not observed in comparison to the control animals. The incidence of malignant tumors in the animals treated with OTS was identical with the one of the control animals. We did, however, find one animal in the test groups that had a carcinoma of the urinary bladder and seven animals with papillomas of the bladder.

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Affiliations

  1. Inst. of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 280, D-6900, Heidelberg, Federal Republic of Germany

    D. Schmähl

Authors
  1. D. Schmähl
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Additional information

The results obtained by experiments in rats allow the conclusion that the essential ingredient of the saccharin impurity, OTS, may possibly have a week carcinogenic effect.

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Schmähl, D. Experiments on the carcinogenic effect of ortho-toluol-sulfonamid (OTS). Z. Krebsforsch. 91, 19–22 (1978). https://doi.org/10.1007/BF00305968

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  • DOI: https://doi.org/10.1007/BF00305968

Key words

  • Saccharin
  • Orthotoluolsulfonamid
  • Carcinogenic activity of saccharin impurities