Summary
Ortho-toluol-sulfonamid was applied to male and female Sprague-Dawley rats in daily doses of 200 mg/kg and 20 mg/kg bodyweight respectively. The maximum dose applied amounted to 17 g/kg. A shortening of the average life expectation was not observed in comparison to the control animals. The incidence of malignant tumors in the animals treated with OTS was identical with the one of the control animals. We did, however, find one animal in the test groups that had a carcinoma of the urinary bladder and seven animals with papillomas of the bladder.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Althoff, J., Cardesa, A., Pour, P., Shubik, P.: A chronic study of artificial sweeteners in Syrian golden hamsters. Cancer Letters 1, 21 (1975)
Munro, I.C., Moodie, C.A., Krewski, D., Grice, H.C.: A carcinogenicity study of commercial saccharin in the rat. Toxicol. Appl. Pharmacol. 32, 513 (1975)
Munro,I.C.: Lecture in Geneva. Joint Meeting WHO and Toxicol. Forum, April 15,1977
Odashima,S.: Lecture in Geneva. Joint Meeting WHO and Toxicol. Forum, April 15,1977
Schmähl, D.: Fehlen einer kanzerogenen Wirkung von Cyclamat, Cyclohexylamin und Saccharin bei Ratten. Arzneimittelforsch. 23, 1466 (1973)
Schmähl, D., Krüger, F.W.: Fehlen einer syncarcinogenen Wirkung von Cyclamat bei der Blasenkrebserzeugung mit Butyl-butanol-nitrosamin bei Ratten. Arzneimittelforsch. 22, 999 (1972)
Stavric, B., Klassen, R., Arnold, W.: Impurities in commercial saccharin. J. AOAC 59, 1051 (1976)
Report on the “Saccharin Meeting”, Center Cont. Educ., Univ. of Nebraska, Omaha, May 1977
Author information
Authors and Affiliations
Additional information
The results obtained by experiments in rats allow the conclusion that the essential ingredient of the saccharin impurity, OTS, may possibly have a week carcinogenic effect.
Rights and permissions
About this article
Cite this article
Schmähl, D. Experiments on the carcinogenic effect of ortho-toluol-sulfonamid (OTS). Z. Krebsforsch. 91, 19–22 (1978). https://doi.org/10.1007/BF00305968
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00305968