Histochemie

, Volume 25, Issue 3, pp 247–255 | Cite as

A histochemical study of liver enzymes involved in glycogen metabolism in the X-irradiated rat

  • G. N. Catravas
  • C. G. McHale
Article

Summary

The liver enzymes responsible for the breakdown and synthesis of glycogen from glucose have been investigated cytochemically in rats exposed to 1200 rads of x-irradiation. It was found that significant changes occur in their activities and that amylophosphorylase and amylo-1,6-glucosidase (debranching enzyme), both of which are responsible for the conversion of glycogen to glucose, are markedly inhibited by radiation. A significant inhibition of the activity of 1,4→1,6 transglucosidase (branching enzyme) was also observed. In contrast, the activity of UDPG-glycogen transglucosylase, which is responsible for the in vivo synthesis of 1,4-polysaccharides, was found to be stimulated.

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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • G. N. Catravas
    • 1
  • C. G. McHale
    • 1
  1. 1.Armed Forces Radiobiology Research Institute, Defense Atomic Support AgencyBethesdaUSA

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