Summary
A cardiac glomus tumor, first described by Masson, was observed in a 28 year old woman who presented symptoms of cardiac dysfunction. Electron microscopic studies disclose a wide range of differentiation of glomus cells from smooth muscle cells to epitheloid cells. The common feature of both cell types include cytoplasmic microfibrils, fusiform condensations and small vesicles. The endothelial cells also show some structural similarities to these glomus cells. The histogenesis of this cardiac tumor is discussed on the basis of its ultrastructure and its uncommon localization. It is concluded that cardiac glomus tumors arise from primitive mesenchymal cells.
Zusammenfassung
Es wird ein Glomustumor nach Masson am Herzen licht- und elektronenmikroskopisch beschrieben. Das Biopsiematerial stammt von einer achtundzwanzig Jahre alten Frau mit cardialer Symptomatik. Die Lokalisation ist für einen Glomustumor ungewöhnlich, da keine Beziehung zur Haut besteht. Elektronenmikroskopisch zeigen die Tumorzellen Übergänge von glatten Muskelzellen bis hin zu Pericyten. Gemeinsame Merkmale sind cytoplasmatische Mikronbrillen, fusiforme Kondensationen und kleine Vesikel. Auffallend sind auch strukturelle Ähnlichkeiten zwischen Endothelzellen und den oben beschriebenen Tumorzellen. Die Histogenese aus einer primitiven Gefäßmesenchymzelle wird anhand der unterschiedlich differenzierten Zellen des organoid aufgebauten Tumors erörtert.
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Riesner, K., Böcker, W. Cardialer Glomustumor, Licht- und elektronenoptische Befunde. Z. Krebsforsch. 84, 59–66 (1975). https://doi.org/10.1007/BF00305689
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DOI: https://doi.org/10.1007/BF00305689