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Direct alkyl chain cleavage after C-hydroxylation of dialkylinitrosamines in rats. A new pathway of the oxidative biotransformation

Direkte Alkylkettenspaltung nach C-Hydroxylierung von Dialkylnitrosaminen in Ratten. Ein neuer Weg der oxidativen Biotransformation

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Summary

Comparative in vivo investigations on the biotransformation of di-n-butylnitrosamine (DBNA) and (2-hydroxybutyl)-n-butylnitrosamine (HBBNA) showed the known ω-oxidation. However, a new metabolic mechanism of direct oxidative alkyl chain cleavage in the vicinity of the hydroxy group of HBBNA could be demonstrated.

Zusammenfassung

Vergleichende Untersuchungen über die Biotransformation von di-n-butylnitrosamin (DBNA) und (2-hydroxybutyl)-n-butylnitrosamin (HBBNA) in vivo zeigten, daß außer der bekannten ω-Oxidation auch direkte oxidative Alkylkettenspaltung neben der OH-Gruppe von HBBNA stattfindet.

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Authors and Affiliations

  1. Forschergruppe Präventivmedizin am Max-Planck-Institut für Immunbiologie, D-7800, Freiburg i. Br., Federal Republic of Germany

    L. Blattmann

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  1. L. Blattmann
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For Prof. Dr. A. Lüttringhaus on occasion of his 70. birthday

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Blattmann, L. Direct alkyl chain cleavage after C-hydroxylation of dialkylinitrosamines in rats. A new pathway of the oxidative biotransformation. Z. Krebsforsch. 88, 315–322 (1977). https://doi.org/10.1007/BF00305369

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  • DOI: https://doi.org/10.1007/BF00305369

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