Summary
The cell damage of the cytostatics Bleomycin and ICRF 159 were studied experimentally by the use of the following parameters: colony survival, colony-size-spectrometry and multiplicity of CHO-Fibroblasts. Series of increasing drug concentrations and simultaneous irradiation with 200 rds were measured. In the above mentioned tests an additive and no potentiating effect of damage by the cytostatics in combination with irradiation of 200 rds was found. Compared with Bleomycin, ICRF 159 showed a higher degree of damage to CHO-Fibroblasts.
Zusammenfassung
Die Zellschädigungen der Cytostatica Bleomycin und ICRF 159 werden mit Hilfe des Koloniebildungstestes, der Koloniegrößenspektrometrie sowie der daraus berechneten Multiplizität am Modell der CHO-Fibroblasten untersucht. Es wird sowohl die Wirkung steigender Konzentrationen der Medikamente als auch der gleichzeitige Einfluß einer Bestrahlung mit 200 rad gemessen. Bei der Kombination Bleomycin oder ICRF 159 mit Röntgenstrahlung findet sich kein potenzierender Effekt, sondern eine additive Schädigung in den angegebenen Testverfahren. ICRF 159 zeigte gegenüber CHO-Fibroblasten eine größere Wirkung als Bleomycin.
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Töllner, D., Hagemann, G. Die Wirkung von Bleomycin, ICRF 159 und simultaner Röntgenbestrahlung auf CHO-Fibroblasten. Z. Krebsforsch. 88, 303–310 (1977). https://doi.org/10.1007/BF00305367
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DOI: https://doi.org/10.1007/BF00305367