Summary
The oncogenic effects of a single dose of N-nitrosopiperidine and N-nitrosomorpholine were examined in Syrian golden hamsters. The main target organ was the respiratory system; the majority of neoplasms was found in the trachea. As ultra-structural investigations could confirm, the tracheal tumours were polyps. Surface lining tumour cells as well as cells in the intermediate epithelial layer still differentiated into ciliated and goblet cells. In addition to the appearance of neoplasms, hyperplastic and dysplastic changes of the tracheal epithelium were seen.
Zusammenfassung
Die onkogene Wirkung einer Einzeldosis von N-nitrosopiperidin und N-nitrosomorpholin wurde am Syrischen Goldhamster untersucht. Es fanden sich vorwiegend Neoplasmen im Respirationstrakt, wobei die Trachea besonders betroffen war. Wie ultrastrukturelle Beobachtungen bestätigten, stellten die Trachealtumoren Polypen dar. Zellen der Oberfläche von Tumoren wie auch der darunter liegenden epithelialen Anteile differenzierten sich noch in Flimmerepithelzellen und Schleimzellen. Neben der Tumorentstehung zeigten sich hyperplastische und dysplastische Veränderungen des Trachealepithels.
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Dedicated to Professor Dr. H. Druckrey on his seventieth birthday.
Supported partially by Public Health Service Contract No. PH 43-68-959 within the National Cancer Institute.
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Althoff, J., Wilson, R., Cardesa, A. et al. Comparative studies of neoplastic response to a single dose of Nitroso compounds. Z. Krebsforsch. 81, 251–259 (1974). https://doi.org/10.1007/BF00305027
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DOI: https://doi.org/10.1007/BF00305027