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Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors

Der Thrombozytenumsatz bei metastasierendem Carcinom und die Wirkung von Plättchenaggregationshemmern

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Summary

Patients with metastatic cancer have a permanent shortening of platelet survival and increased platelet consumption. Acetylsalicylic acid or dipyridamole in doses known to inhibit platelet aggregation, had no effect on platelet consumption.

Zusammenfassung

Bei Patienten mit metastasierendem Carcinom ist die Überlebenszeit der Blutplättchen durch gesteigerten Umsatz verkürzt. Acetylsalicylsäure und Dipyridamol in einer für die Plättchenaggregationshemmung ausreichenden Dosis hatten keinen Einfluß auf den Plättchenverbrauch.

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References

  • Abrahamsen,A.F.: A modification of the technique for 51Cr labelling of blood platelets giving increased circulating platelet radioactivity. Scand. J. Haemat. 5, 53 (1968)

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  • Abrahamsen,A.F.: The effects of acetylsalicylic acid and dipyridamole on platelet economy in metastatic cancer. Scand. J. Haemat. 9, 562 (1972)

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  • Harker,L.A., Slichter,A.J.: Platelet and fibrinogen consumption in man. New Engl. J.Med. 287, 999 (1972)

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Authors and Affiliations

  1. General Department, Norwegian Radium Hospital, Oslo 3, Norway

    A. F. Abrahamsen

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  1. A. F. Abrahamsen
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Abrahamsen, A.F. Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors. Z. Krebsforsch. 86, 109–111 (1976). https://doi.org/10.1007/BF00304941

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  • DOI: https://doi.org/10.1007/BF00304941

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