Skip to main content
SpringerLink
Log in

Carcinogenic effects of different nitroso-compounds in chinese hamsters II. N-nitrosomorpholine and N-nitrosopiperidine

Carcinogene Wirkungen verschiedener Nitrosoverbindungen auf den Chinesischen Zwerghamster II. N-Nitrosomorpholin und N-Nitrosopiperidin

  • Published:
Zeitschrift für Krebsforschung und Klinische Onkologie Aims and scope Submit manuscript

Summary

A total of 320 Chinese hamsters (Cricetulus griseus) (CH) were subcutaneously (s. c.) treated with 1/5, 1/10, or 1/20 LD50 of N-nitrosomorpholine (NM) or N-nitrosopiperidine (NP). In the CH, NM and NP both produced up to a 100% rate of papillomas of the cheek pouch, tongue, pharynx, esophagus and forestomach. Occasionally squamous cell carcinomas also developed in these organs. A high rate of hepatomas was realized by NP.

Zusammenfassung

320 Chinesische Zwerghamster (Cricetulus griseus) (CH) erhielten subcutan 1/5, 1/10 oder 1/20 der LD50 N-Nitrosomorpholin (NM) oder N-Nitrosopiperidin (NP). Beide Substanzen führten zu Papillomen in 3 Backentaschen, Zunge, Pharynx, Oesophagus und Vormagen. In einigen Fällen fanden sich darüber hinaus in den Organen auch Plattenepithelcarcinome. Weiterhin wurde nach Behandlung mit NP eine hohe Hepatomrate beobachtet.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Haas, H., Mohr, U., Krüger, F.W.: Comparative studies with different doses of N-nitrosomorpholine, N-nitrosopiperidine, N-nitrosomethylurea and dimethylnitrosamine in Syrian golden hamsters. J. nat. Cancer Inst. 51, 1295 (1973)

    Google Scholar 

  • Mohr, U., Reznik, G., Reznik-Schüller, H.: Carcinogenic effects of N-nitrosomorpholine and N-nitrosopiperidine on European hamsters (Cricetus cricetus L.). J. nat. Cancer Inst. 53, 231 (1974)

    Google Scholar 

  • Reznik,G., Mohr,U., Kmoch,N.: Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-Diethylnitrosamine. (In prep.)

  • Weil, C.S.: Tables for convenient calculations of effective dose(LD50 or ED50) and instructions in their use. Biometrics 8, 249 (1952)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Experimentelle Pathologie, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Federal Republic of Germany

    G. Reznik, U. Mohr & N. Kmoch

Authors
  1. G. Reznik
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Mohr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Kmoch
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reznik, G., Mohr, U. & Kmoch, N. Carcinogenic effects of different nitroso-compounds in chinese hamsters II. N-nitrosomorpholine and N-nitrosopiperidine. Z. Krebsforsch. 86, 95–102 (1976). https://doi.org/10.1007/BF00304939

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00304939

Keywords

Search

Navigation