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Alternating six-drug combination chemotherapy induction for intermediate and high-grade non-Hodgkin's lymphoma

  • Original Articles
  • Combination Chemotherapy, Non-Hodgkin's Lymphoma, Alternating Regime
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Summary

31 patients with intermediate and high-grade non-Hodgkin lymphomas were treated by a six-drug alternating regime comprising four cycles of 200 mg/m2 i.v. methotrexate on days 8, 15, 28 and 35, 50 mg/m2 i.v. Adriamycin on day 1, 40 mg/m2 oral prednisolone on days 1–7 and 21–27, 120 mg/m2 i.v. etoposide on days 21–23, 600 mg/m2 i.v. cyclophosphamide on day 21 and 1.4 mg/m2 i.v. vincristine on day 1 (MAPECO). In all, 3 patients had stage I disease, 12 stage II, 6 stage III and 10 stage IV. Of 28 evaluable patients, 19 were complete responders (68%) and 9 were partial responders (32%); at 2 years, the actuarial relapse-free survival of the 19 patients achieving complete remission is 80%, and 5 patients remain in complete remission at 3 years. This is a preliminary report of an effective intensive regime with acceptable toxicity.

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Authors and Affiliations

  1. Cancer Research Campaign, Department of Radiation Oncology, Clatterbridge Hospital, Bebington, L63 4JY, Wirral, Merseyside, UK

    John A. Green, R. Douglas Errington & Hilmar M. Warenius

  2. Department of Pathology, University of Liverpool, Prescot Street, L7 8XP, Liverpool, UK

    John R. G. Nash

  3. Mersey Regional Centre for Radiotherapy and Oncology, Clatterbridge Hospital, Bebington, L63, 4JY, Wirral, Merseyside, UK

    Michael A. Coe

Authors
  1. John A. Green
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  2. R. Douglas Errington
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  3. John R. G. Nash
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  4. Michael A. Coe
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  5. Hilmar M. Warenius
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Green, J.A., Errington, R.D., Nash, J.R.G. et al. Alternating six-drug combination chemotherapy induction for intermediate and high-grade non-Hodgkin's lymphoma. Cancer Chemother. Pharmacol. 24, 326–328 (1989). https://doi.org/10.1007/BF00304767

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  • DOI: https://doi.org/10.1007/BF00304767

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