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Effects of two pyridinalalkyliminerhodium(I) complexes in mice bearing MCa mammary carcinoma

  • Original Articles
  • Rh (I) Complexes, MCa Mammary Carcinoma, Antimetastatic Action
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Summary

The examination of the differential effects of two square-planar rhodium(I) complexes on primary tumor growth and on the formation of spontaneous and artificially (i.v. tumor injection) induced lung metastases of MCa mammary carcinoma suggests different mechanisms of action, depending on the chemical characteristics of the compound used. Of the two complexes used, cyclooctadiene(2-pyridinalmethylimine)Rh(I) chloride and cyclooctadiene(2-pyridinalisopropylimine)Rh(I) chloride, the former compound confirmed the antineoplastic action previously shown in the Lewis lung carcinoma model. The activity of this derivative on lung metastasis formation seems to be unrelated to a cytotoxic action for tumor cells localized in the lungs. More likely, it appears that modifications occurring at the primary tumor level, probably different from a tumor-cell-directed lethality, are responsible for the reduction of spontaneous lung metastasis formation observed in treated animals. The hyperplasia of the spleen induced in treated animals seems to suggest that this compound is endowed with properties typical for biological response modifiers.

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Authors and Affiliations

  1. Department of Chemical Sciences, University of Trieste, I-34100, Trieste, Italy

    Giovanni Mestroni & Grazia Zassinovich

  2. Institute of Pharmacology, Faculty of Pharmacy, University of Trieste, via A. Valerio 32, 34127, Trieste, Italy

    Gianni Sava, Sonia Zorzet & Sabrina Pacor

Authors
  1. Gianni Sava
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  2. Sonia Zorzet
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  3. Sabrina Pacor
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  4. Giovanni Mestroni
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  5. Grazia Zassinovich
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Additional information

This work was supported by grants from the Italian Ministry of Education (MPI 40% and 60%)

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Sava, G., Zorzet, S., Pacor, S. et al. Effects of two pyridinalalkyliminerhodium(I) complexes in mice bearing MCa mammary carcinoma. Cancer Chemother. Pharmacol. 24, 302–306 (1989). https://doi.org/10.1007/BF00304762

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  • DOI: https://doi.org/10.1007/BF00304762

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