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Somatostatin-14-like immunoreactive neurons and fibres in the human olfactory bulb

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Summary

This study describes the morphological features and the distribution pattern of neurons in the human olfactory bulb which are immunoreactive for an antiserum against the neuropeptide somatostatin-14.

Immunoreactive nerve cell bodies were mainly found in the white matter surrounding the cell clusters of the anterior olfactory nucleus. Some immunoreactive neurons were also found scattered throughout the anterior olfactory nucleus and the deeper parts of the inner granule cell layer. Only a few immunoreactive neurons were localized in the glomerular layer and the outer granule cell layer.

Immunoreactive fibres were found in all layers of the olfactory bulb. In addition, an impressive number of coiled and kinked immunoreactive fibres were localized within the anterior olfactory nucleus forming a dense plexus. Accumulations of twisted and coiled branches of immunoreactive fibres were rarely found either surrounding or within the olfactory glomerula.

The characteristics of somatostatin-14 immunoreactive neurons as seen in the combined pigment-Nissl preparation were studied after decolourizing the chromogen and restaining the preparations with aldehydefuchsin in order to demonstrate the lipofuscin pigment and gallocyanin chrome alum for Nissl material. About 90% of the immunoreactive neurons studied in this manner turned out to be devoid of lipofuscin granules. The remaining 10% displayed different patterns of pigmentation.

These findings suggest the presence of different types of somatostatin-14-like immunoreactive neurons in the olfactory bulb of the human adult.

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Authors and Affiliations

  1. Zentrum der Morphologie, J.W. Goethe-Universität, Theodor Stern Kai 7, D-6000, Frankfurt am Main 70, Federal Republic of Germany

    T. G. Ohm & E. Braak

  2. Institut für Pathologie, Universität von Basel, CH-4056, Basel, Switzerland

    A. Probst

Authors
  1. T. G. Ohm
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  2. E. Braak
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  3. A. Probst
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Ohm, T.G., Braak, E. & Probst, A. Somatostatin-14-like immunoreactive neurons and fibres in the human olfactory bulb. Anat Embryol 179, 165–172 (1988). https://doi.org/10.1007/BF00304698

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  • DOI: https://doi.org/10.1007/BF00304698

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