Summary
Three new cases of “mirror image” duplication of a chromosome 21 are studied. In the first case the extra chromosome derived from a single paternal chromosome 21 by intrachromosomal interchange. The analysis of similar published cases suggests that this mechanism may predominate, but interchromosomal interchange, para- and pericentric inversion are likely as well.
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Pfeiffer, R.A., Loidl, J. Mirror image duplications of chromosome 21. Three new cases and discussion of the mechanisms of origin. Hum Genet 62, 361–363 (1982). https://doi.org/10.1007/BF00304558
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DOI: https://doi.org/10.1007/BF00304558