Summary
In an attempt to improve the resolving power of the conventional methods used to karyotype chromosomes, a procedure is presented here which allows the sequential study of selected R-banded metaphases by light and electron microscopy. Small sub-bands, not visible by light microscopy, could be clearly identified.
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Goyanes, V.J., Méndez, J. Karyotyping chromosomes by electron microscopy. II. A method for the sequential examination of spread and banded metaphases by light and electron microscopy. Hum Genet 62, 355–357 (1982). https://doi.org/10.1007/BF00304556
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DOI: https://doi.org/10.1007/BF00304556